Multicenter Study in Postmenopausal Women With Osteoporosis, ALVOBOND

1. Postmenopausal women with osteoporosis willing to sign an informed consent form (ICF)and able to undergo protocol related procedures. 2. A baseline dual-energy x-ray absorptiometry (DXA) scan with a T score ≤-2.5 and * 4.0 at the LS (L1 to L4)and/or, total hip, and/or femoral neck. 3. Age: ≥50 years. 4. Female subject is postmenopausal according to 1 of the following criteria: 1. Spontaneous amenorrhea for ≥12 consecutive months 2. Biochemical criteria of menopause, follicle-stimulating hormone, \>40 IU/L except surgically sterile 3. Having had bilateral oophorectomy ≥6 weeks prior to Screening 5. Willing to receive calcium plus vitamin D supplements. 6. At least 2 consecutive evaluable lumbar vertebrae and at least 1 evaluable hip. Exclusion Criteria 1. Evidence of clinically relevant pathology, especially prior diagnosis of bone disease, or any uncontrolled condition that will affect bone metabolism 2. History and/or presence of 1 severe or more than 1 moderate vertebral fractures confirmed by x-ray. 3. History of hip fracture 4. Presence of active healing fractures 5. Osteonecrosis of the jaw (ONJ) or risk factors for ONJ such as invasive dental procedures 6. Evidence of hypo/hypercalcemia at Screening 7. Known vitamin D deficiency 8. Known intolerance to calcium and vitamin D supplement.