This study investigates the effects of acetaminophen on behavioral, physiological, and self-report fear responses.
As acetaminophen blunts the experience of physical, social, and empathic pain, it is important to investigate whether there are other aversive states that the drug also provides relief from. If there are others, this may suggest overlapping mechanisms involved in these affective evaluations, all of which are interrupted by acetaminophen. The emotion of fear is aversive, yet it is distinct from both physical and social pain. The present study will investigate the effects of acetaminophen on the subjective experience of fear as well as its behavioral outcomes. While blocking adaptive behavioral responses to fear could potentially be problematic in some dangerous situations, it may also be helpful for those with anxiety-related disorders. If individuals on acetaminophen can step farther away from safety on a virtual plank 80 stories above the ground, then perhaps acetaminophen can allow anxious individuals to step farther from their comfort zone in real life. Importantly, if acetaminophen blunts the fear response, this would mean that the drug blocks aversive feelings beyond emotional and physical pain. The extent of its effects will warrant further investigation for a greater understanding of emotional evaluations.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
266
2 x 500 mg acetaminophen (one time)
2 x 500 mg microcrystalline cellulose (one time)
University of Guelph
Guelph, Ontario, Canada
Walking speed on plank in virtual reality
Farthest distance reached on plank / time to get there
Time frame: 1 hour after taking acetaminophen or placebo
Distance walked on plank
(Unless there are ceiling effects in which \>90% of people make it to the end.) Measured in cm walked on a 2 m wooden plank before deciding to turn around and walk back.
Time frame: 1 hour after taking acetaminophen or placebo
Proportion of time spent looking down at the plank
We will record what participants see in virtual reality while doing the plank walk, and then code the footage to calculate the proportion of time on the plank participants spent looking down at the plank (indicating more anxiety about falling off).
Time frame: 1 hour after taking acetaminophen or placebo
Decision on whether to do the plank walk again with virtual spiders
After doing the plank walk, participants will be offered an optional second chance to try the same plank walk again but this time with virtual giant spiders around them.
Time frame: 1 hour after taking acetaminophen or placebo
Verbal Self-Report Fear
While participants are in virtual reality, we will ask them to rate their fear verbally twice, once when they first step onto the plank, and once when they have changed direction (during which the plank tends to shake). They will answer from 0 (no fear or anxiety) to 10 (extreme fear or anxiety). For those who decide to do the plank walk again with virtual giant spiders, they will also rate their self-reported fear in the same manner twice, once when the spiders first appear, and once when they are on their way back to the virtual elevator while surrounded by giant spiders.
Time frame: 1 hour after taking acetaminophen or placebo
Written Self-Report Fear
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After taking off the headset, participants will answer two survey questions. The first is, "How scary do you think most people would agree the act of walking on a virtual plank is?" They will answer on an 11-point scale (0 = Not at all scary, 5 = Moderately scary, 10 = Extremely scary). They will also be asked "How fearful, scared, nervous, or anxious did you personally feel when walking on the virtual plank?" (0 = Not at all fearful or anxious, 5 = Moderately fearful or anxious, 10 = Extremely fearful or anxious). Those who choose to do the second optional plank walk with virtual spiders will answer the same questions about that experience afterwards.
Time frame: 1 hour after taking acetaminophen or placebo
Heart rate
Average heart rate while on the plank walk, measured with a Polar Verity Sense optical heart rate sensor on forearm.
Time frame: 1 hour after taking acetaminophen or placebo
Time to take first step onto plank
Number of seconds it takes participants to leave the virtual elevator for the plank overlooking a virtual 80-story drop.
Time frame: 1 hour after taking acetaminophen or placebo
Speed towards virtual elevator after turning around on plank,
Amount of time it takes them to make it back to the starting point after turning around on the plank. It is not clear whether someone who walks faster would be doing so to get back to the feeling safety quicker or because they are less cautious due to less fear, and so this is a secondary measure.
Time frame: 1 hour after taking acetaminophen or placebo
Time before needing a break or quitting the virtual reality plank walk
(Unless there are ceiling effects in which \>90% of participants do not quit early or need a break). Amount of time before a participant takes their headset off early, to quit or for a break, due to being overwhelmed.
Time frame: 1 hour after taking acetaminophen or placebo