Many studies have shown that patients with depression had weak brain region connections and low levels of activation of the prefrontal lobe when brain activity was active and that patients with depression have a negative attentional bias, and the patient's abnormal attentional allocation may stem from a loss of attention avoidance of negative cues and a loss of attention preference for positive cues. Here use the near-infrared, eye movement to evaluate the cognitive function in patients with depression. The purpose of the study is to explore the correlation between depressed symptom and cognition function among the depression patients and the difference between first-onset of depressed patients and those is recurrent.
This study will comprise 200 patients with depression disorder. All participants will be assessed and clinically examined at baseline, and all patients are encouraged to follow up at week 12. Baseline assessments will include demographics, menstrual records for female, comprehensive medical history, physical examination, near-infrared, eye movement and laboratory work (e.g., hormones). The follow-up of patients will include laboratory work, near-infrared, eye movement. Clinical symptoms will be assessed by HAMD-17,HamiltonAnxietyScale, and Young Mania Rating Scale. The cognitive function will be assessed at baseline and week 12 .The primary outcomes will be the near-infrared , eye movement . Secondary outcomes will include overall psychiatric symptomatology, cognitive function, and other biological data.
Study Type
OBSERVATIONAL
Enrollment
200
No intervention
Mental Health Institute of 2nd Xiangya Hospital,CSU
Changsha, Hunan, China
Change in Hamilton Depression Scale (HAMD-17)
Scores ranging from 0-54, with higher scores indicating more severe symptoms
Time frame: Baseline, the first month, the second month and the third month
Change in Pittsburgh Sleep Quality Scale (PSQI)
Scores ranging from 0-21, with higher scores indicating more severe symptoms
Time frame: Baseline, the first month, the second month and the third month
Changes in Beck Suicidal Scale Inventory (BSI)
Scores ranging from 0-100, with higher scores indicating more severe symptoms
Time frame: Baseline, the first month, the second month and the third month
Changes in selective attention through eye-tracking task.
Eye-tracking task was performed using the free-viewing paradigm. By presenting images of irritable, threatening,positive, and neutral emotional scenes, the subject's selective attention was measured.
Time frame: Baseline, the first month, the second month and the third month
Changes in cerebral blood flow of left DLPFC through Near Infrared Spectroscopy (fNIRS)
Measuring the hemoglobin concentration of cerebral cortex during verbal fluency test and emotion recognition test.
Time frame: Baseline, the first month, the second month and the third month
Change in Hamilton Anxiety Scale (HAMA)
Scores ranging from 0-56, with higher scores indicating more severe symptoms
Time frame: Baseline, the first month, the second month and the third month
Change in Young's Mania Scale (YMRS)
Scores ranging from 0-60, with higher scores indicating more severe symptoms
Time frame: Baseline, the first month, the second month and the third month
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