The purpose of the study is to assess the physiologic, immunologic, and mental health effects of an exercise and pulmonary rehabilitation program on patients with Long COVID-19 (LC).
1.0 Objectives 1.1 Describe the purpose, specific aims, or objectives. The purpose is to assess the physiologic, immunologic, and mental health effects of a rehabilitation program on patients with Long COVID-19 (LHC). 1.2 State the hypotheses to be tested. Long COVID-19 Patients who enroll and complete a 10 week program of Physiologic and Psychological Rehabilitation will have reduced Long COVID-19 Symptoms, Improved Physical Status, Reduced Inflammatory Markers, and Augmented Psychological Well Being.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
21
The subject will receive on site standard pulmonary and exercise rehabilitation, educational instruction on balance and strength training, stretching, nutrition, hydration, pacing, proper breathing, small or mini-lectures, and information on relaxation techniques.
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, United States
Change in aerobic capacity (Peak Oxygen Uptake) at 10 weeks after rehabilitation comprehensive (normal intensity) pulmonary rehabilitation program.
Cardopulmonary - Exercise Outcomes.
Time frame: 10 weeks
Short Form (SF-36)
Quality of Life - 36 Item Short Form Survey. 8 subdomains - Potential scores 0 to 100 (100 being best) in each domain.
Time frame: 10 weeks
Fatigue Severity Scale (FSS)
Change in a Fatigue Score - 9 questions -1 (strongly disagree) to 7 (strongly agree). Total score from 7 to 54. Lower numbers are better.
Time frame: 10 weeks
General Anxiety Disorder Screener (GAD-7)
Change in Anxiety scores - 7 questions. 0-Not at all to 3 Nearly Every Day - Scores from 0-21. Lower numbers are better.
Time frame: 10 weeks
Pittsburg Sleep Quality Score (PSQI)
Change in Sleep Quality Index - Scores from 0 to 42. Lower scores are better. A score \> 5 indicates poor sleep quality.
Time frame: 10 weeks
Modified Medical Research Council Dyspnea Scale (mMRC)
Score ranges from 0 to 4. Lower scores are better.
Time frame: 10 weeks
Modified DePaul Assessment for Post-Exertional Malaise (DSQ-PEM)
Questions 6-10 Specific to PEM. All questions are Yes/No, No is best.
Time frame: 10 weeks
Patient Health Questionnaire (PHQ-9)
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Change in Depression scores - 9 questions that are scored from 0-3. Total scores 0-27. Lower scores are better.
Time frame: 10 weeks