The aim of this 16-week group aerobic training program, delivered remotely via video-conferencing, is to assess program feasibility, and determine if program increases physical activity in adolescents after heart transplant.
Orthotopic heart transplant (OHT) is the definitive therapy for children with cardiac disease, however, survival after transplant is limited, and quality of life after transplant is less than healthy peers'. The transplanted heart usually works well, pumping blood as well as most healthy hearts. As such, the American Heart Association recommends no specific exercise related restrictions for heart transplant recipients. Although most children have normal cardiac function after OHT, children with transplanted hearts have impaired exercise performance, and do not exercise as much as their peers. This finding is concerning, as impaired exercise tolerance is associated with reduced survival, diminished health related quality of life, and depression and anxiety. These factors negatively impact adherence, and further limit graft survival. Thus, identifying interventions that positively impact physical activity and promote graft longevity, like individualized exercise programs, should be a priority for post-transplant care. Investigators propose that increasing physical activity in children and adolescents after OHT may be a critical modifiable method for increasing graft longevity and improving quality of life. Investigators will explore this through a pilot program. Participants will wear an activity monitor to record physical activity, parents/caregivers and participants will complete surveys, and participants will engage with psychologists and exercise physiologists.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
23
At-home, aerobic group exercise program facilitated by exercise physiologist via video format, 3 times a week for 16 weeks.
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Study feasibility assessed by participation in training sessions
Attendance at assigned training sessions
Time frame: 16 weeks
Study feasibility evaluated by participants' engagement on the activity monitor application
Days of logged activity on the MyHeart application
Time frame: 24 weeks
Study feasibility assessed by participants' engagement with exercise physiologist
Participants' attendance at biweekly meetings with exercise physiologist
Time frame: 24 weeks
Physical activity of participants
Time spent at target heart rate
Time frame: 24 weeks
Health Related Quality of life
Health related quality of life (HRQL) will be measured by participants' responses to Pediatric Quality of Life (PEDSQL) questionnaire, generating scores from 0-100 with a higher score indicating better quality of life.
Time frame: 24 weeks
Psychological well-being
Psychological well-being will be evaluated by participants' responses on questionnaires using Patient Reported Outcome Measurement Information System (PROMIS). PROMIS measures generate T-scores. T-scores are standard scores with a mean of 50 and standard deviation of 10 in a reference population (usually U.S. general population) with a higher score indicating more of the psychological concept being measured.
Time frame: 24 weeks
Perceived exercise barriers or exercise barriers
Exercise barriers will be measured by analysis of survey responses related to physical activity practices
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Time frame: 24 weeks
Participants' overall program satisfaction
Participants' overall program satisfaction will be analyzed by review of completed post-intervention questionnaires
Time frame: 24 weeks