The Role of TextRAd on Detection of Liver Metastasis in Rectal Cancer

East Suffolk and North Essex NHS Foundation Trust113 enrolled

Overview

This is a retrospective analysis of all patients diagnosed with LARC who received NCRT and had MRI scans between 2003-2014 at East Suffolk and North Essex NHS Foundation Trust. Region of interest was drawn around the tumor or its location on T2 MRI images. Six texture parameters were systematically extracted from Textural histograms of post-treatment scans. These parameters were examined to determine their ability to predict local recurrence and distant metastases through Kaplan-Meier survival curves and log-rank tests.

Study Type

OBSERVATIONAL

Enrollment

113

Conditions

Rectal Cancer

Interventions

MRIDIAGNOSTIC_TEST

Texture analysis (TA) is a novel imaging biomarker that can assess heterogeneity in MRIs by measuring grey-level intensities distribution. This study hypothesizes that TA of MRI is an imaging biomarker that can predict local recurrence and distant metastasis.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * All subjects must have MRI post-Chemotherapy treatment to detect the response to Neoadjuvant treatment and compare it to pre-treatment scans to easily determine if there were a posttreatment liver metastasis. * Locally advanced rectal cancer (LARC) = MRI stage: T3/T4 and/or N1/N0. Exclusion Criteria: * Distant metastases. * Synchronous tumour.

Locations (1)

East Suffolk and North Essex NHS Foundation Trust

Ipswich, United Kingdom

Outcomes

Primary Outcomes

Local recurrence of rectal cancer

Time frame: 120 months

Data from ClinicalTrials.gov

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