Platelet Transfusion Refractoriness is one of the severe complications after multiple transfusions in patients with severe thrombopenia. Platelet Transfusion Refractoriness is characterized by inefficient transfusion and arise from allo-antibodies specific of platelets antigenes, mostly carried by HLA-I molecules.
A preliminary study has shown different isotypes of anti-HLA I in patients with Platelet Transfusion Refractoriness. Our hypothesis is that the type of anti-HLA I antibodies (recognised epitope, quantity, isotype) should establish predictive and diagnostic criteria for Platelet Transfusion Refractoriness.
Study Type
OBSERVATIONAL
Enrollment
50
platelet transfusion realised for Hematopoietic stem cells graft or for acute leukemia
Institut de cancérologie Strasbourg Europe
Strasbourg, France
Research of predictive criteria of Platelet transfusion refractoriness
Characterisation of anti-HLA I antibodies (recognised epitopes and isotypes) associated to Platelet transfusion refractoriness
Time frame: blood samples before the transfusion of each chemotherapy cycle
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