Although systemic inflammatory response induced by cardiopulmonary bypass is believed as one of main reasons for these adverse events, the involved mechanism is still unclear.This cohort study would include patients undergoing on-pump valve surgery or CABG. By detecting the changes of immune cell expression profile and inflammatory related substances in blood, the spatiotemporal change curve of immune function of patients is drawn for avoiding or treating adverse events.
Study Type
OBSERVATIONAL
Enrollment
120
On-pump valve surgery or coronary arterial bypass grafting
West China Hospital of Sichuan University
Chengdu, Sichuan, China
RECRUITINGcomposite outcome
the incidence of vital organ injury, which is defined as a composite measure, including postoperative death, vital organ dysfunction, and mechanical ventilation duration greater than 24 hours. And the vital organ dysfunction includes new kidney injury, long-term low cardiac output, severe liver function injury and neurological function injury.
Time frame: From the beginning of surgery to 30 days after surgery or to discharge from hospital
Infection
Time frame: From the beginning of surgery to 30 days after surgery or to discharge from hospital]
MACCE
including all-cause mortality, myocardial infarction, severe arrhythmias and stroke
Time frame: From the beginning of surgery to 30 days after surgery or to discharge from hospital]
Acute lung injury
Acute onset of bilateral infiltrates on the chest readiograph and hypoxaema(PaO2/Fi O2 ratio \<300) in the absence of clincial evidence of left atrial hypertension
Time frame: From the beginning of surgery to 30 days after surgery or to discharge from hospital]
Gastrointestinal complications
including gastrointestinal bleeding and intestinal ischemia
Time frame: From the beginning of surgery to 30 days after surgery or to discharge from hospital
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