Effect of Acitretin Versus Narrowband Ultraviolet B on Neopterin Level in Psoriatic Patients .

Phase 4UnknownNCT05401006

South Valley University30 enrolled

Overview

To evaluate effect of acitretin versus Narrowband UVB on serum level of neopterin in psoriatic patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Psoriasis

Interventions

Acitretin 25Mg CapDRUG

Acitretin is an oral retinoid (a derivative of vitamin A) given in a dose 0.25-1 mg /kg/day for 3months in psoriatic patients

Narrowband ultraviolet BRADIATION

Narrowband UVB is the most common form of phototherapy used to treat psoriasis, given 2-3 sessions per week for 3 successive months

Eligibility

Sex: ALLMin age: 15 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with psoriasis diagnosed clinically Aged (15-60). Exclusion Criteria: * Patient with history of skin cancer. * Patient with history of photosensitivity. * Pregnancy and lactation. * Liver failure. * Renal failure. * Patient with psoriatic artheritis. * Patient with allergy to product or any of its components. * Patient with poorly controlled dyslipidemia. * Patient receiving tetracyclines.

Locations (1)

South Valley University

Qina, Egypt

Outcomes

Primary Outcomes

Serum Neopterin in psoriasis

Measurement of Neopterin in psoriatic patients before and after treatment with NB-UVB, Acitretin and combination of both modalities using ELISA (enzyme-linked immunosorbent assay).

Time frame: 3 Months

Secondary Outcomes

Treatment of psoriasis

Clinical evaluation: Assessment of disease severity will be performed by using psoriasis area severity index (PASI score) before and after treatment with NB-UVB, Acitretin and combination of both modalities.

Time frame: 3 Months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.