Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease

Western Sydney Local Health District60 enrolled

Overview

People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may contribute, in part, to high blood pressure in this condition. Nitrate is found in high concentrations naturally in beetroots, and increases NO. The aim of this study is to determine if beetroot juice reduces blood pressure in hypertensive people with ADPKD.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Autosomal Dominant Polycystic Kidney Hypertension Endothelial Dysfunction

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of Autosomal Dominant Polycystic Kidney Disease * Age \> 18 years old * Estimated Glomerular Filtration Rate (eGFR) \> 30 mL/min/1.73m2 * Treatment with at least one anti-hypertensive Exclusion Criteria: * Inability to provide Informed Consent * Labile, unstable, uncontrolled hypertension and/or changes in BP treatment 28 days prior to the screening visit * Non-compliance with study procedures and/or daily BP measurements during the screening period * Medical conditions or treatments that might interfere with the generation of NO metabolites or the primary endpoint (e.g. nitrate drugs; cigarette smoking; unwilling to stop using antiseptic mouthwash; severe, uncontrolled hypercholesterolemia; pregnancy or post-partum and lactating) * Any serious or other medical conditions that might interfere with follow-up or stability of blood pressure (e.g. current active malignancies; uncontrolled diabetes mellitus with elevated HbA1c \> 10%) * Dislike of taste of beetroot juice * Allergy to beetroot * Enrolled in other clinical trials

Locations (2)

Westmead Hospital

Sydney, New South Wales, Australia

Westmead Institute for Medical Research

Westmead, New South Wales, Australia

Outcomes

Primary Outcomes

Change in Clinic Systolic and Diastolic Blood Pressure From Baseline to 4 Weeks (End of Study)

Change in systolic and diastolic blood pressure over two time points - from readings taken at baseline (visit 1) compared with readings taken at 4 weeks (which was the end of the study; visit 3)

Time frame: 4 weeks

Secondary Outcomes

Average Change in Daily Home Systolic and Diastolic Blood Pressure Per Week, Over 4 Weeks

Reported change in blood pressure is average change per week, over 4 weeks

Time frame: 4 weeks

Urinary Albumin to Creatinine Ratio at Baseline and at 4 Weeks (End of Study)

Time frame: 4 weeks

Change in Serum Nitric Oxide Metabolite Levels From Baseline to 4 Weeks (End of the Study)

Time frame: 4 weeks

Change in Salivary Nitric Oxide Metabolite Levels From Baseline to 4 Weeks (End of the Study)

Time frame: 4 weeks

Serum Asymmetric Dimethylarginine at Baseline and at 4 Weeks (End of the Study)

Asymmetric dimethylarginine (ADMA) which is a recognized marker of endothelial dysfunction and inhibitor of nitric oxide

Time frame: 4 weeks