Diseases of dementia are chronic, untreatable, and cause a massive burden of morbidity. In this proposal, we seek to tackle the problem of better, earlier, and more efficient diagnosis using deuterium metabolic imaging (DMI). The study is divided in two sub-studies: 1) optimization and simplification of DMI protocols, and 2) a cross-sectional study of DMI in Alzheimer's patients and healthy controls.
Study Type
OBSERVATIONAL
Enrollment
21
MRI after oral administration of 75g of \[6,6'-2H2\]glucose.
Aarhus University
Aarhus, Denmark
Deuterium Metabolic Imaging
Glucose concentration in whole-brain referenced to baseline scan (sub-study 1).
Time frame: Up to 150 mins after 2H-glucose ingestion
Deuterium Metabolic Imaging
Lactate concentrations in whole-brain referenced to baseline scan (sub-study 1).
Time frame: Up to 150 mins after 2H-glucose ingestion
Deuterium Metabolic Imaging
Glx concentrations in whole-brain referenced to baseline scan (sub-study 1).
Time frame: Up to 150 mins after 2H-glucose ingestion
Deuterium Metabolic Imaging
Lactate/glx ratio in the tempo-parietal cortex (sub-study 2).
Time frame: Up to 150 mins after 2H-glucose ingestion
Deuterium Metabolic Imaging
Lactate/glx ratio in the hippocampus (sub-study 2).
Time frame: Up to 150 mins after 2H-glucose ingestion
Deuterium Metabolic Imaging
Lactate/glx ratio in the posterior cingulum (sub-study 2).
Time frame: Up to 150 mins after 2H-glucose ingestion
Deuterium Metabolic Imaging
Simpler DMI quantifications, including reference to external phantoms and internal reference, in the same regions defined in primary outcomes.
Time frame: Up to 150 mins after 2H-glucose ingestion
Blood samples
Glucose
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Time frame: Up to 150 mins after 2H-glucose ingestion
Blood samples
2H-enrichment
Time frame: Up to 150 mins after 2H-glucose ingestion
FDG-PET from the records (sub study 2)
Brain glucose uptake
Time frame: At time of Deuterium Metabolic Imaging
Cognitive tests from the records (sub study 2)
The Mini-Mental State Exam (0-30, 30 is best)
Time frame: At time of Deuterium Metabolic Imaging
Cognitive tests from the records (sub study 2)
Addenbrooke's Cognitive Examination (0-100, 100 is best)
Time frame: At time of Deuterium Metabolic Imaging
Cerebrospinal fluid biochemistry from the records (sub study 2)
Total tau protein
Time frame: At time of Deuterium Metabolic Imaging
Cerebrospinal fluid biochemistry from the records (sub study 2)
Phosphorylated tau
Time frame: At time of Deuterium Metabolic Imaging
Cerebrospinal fluid biochemistry from the records (sub study 2)
Amyloid
Time frame: At time of Deuterium Metabolic Imaging