Brief Summary: This is a multicentric, retrospective, real-world study to investigate the surgical outcomes of minimally invasive surgery compared with open surgery for Perihilar Cholangiocarcinoma (PHC), with the perioperative characteristics and long-term overall survival being compared. We aimed to find out whether the minimally invasive surgery is safe or feasible for PHC. And we also want to find out patients with what kind of characteristic can be benefit from the minimally invasive surgery compared with the open approach.
Study Type
OBSERVATIONAL
Enrollment
783
This is an observational study without any intervention.
Department of Biliary and Pancreatic Surgery, Tongji Hospital, Affiliated Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
Postoperative length of stay
defined as the time from being admitted to hospital to discharge
Time frame: up to 90 days
Overall survival
defined as the duration from the first day after surgery to either the date of death or the last follow-up
Time frame: through study completion, an average of 5 year
Operation time
defined as the time from skin incision or trocar placement to complete skin closure
Time frame: intraoperative
postoperative complications
Postoperative complications were reviewed within 90 days after surgery and graded according to Clavien-Dindo (CD) classification system.Postoperative biliary leakage, hemorrhage, and liver failure were defined and classified according to the criteria set out by the International Study Group of Liver Surgery (ISGLS). Wound infection was defined as purulent drainage from the incision or/and positive findings of culture of the fluid or tissue aseptically obtained from the incision.
Time frame: up to 90 days
Reoperation within 90 days
defined as any reoperation within 90 days
Time frame: up to 90 days
Mortality
defined as any death within 30 days and 90 days, respectively
Time frame: up to 90 days
Readmission within 90 days
defined as any readmission within 90 days
Time frame: up to 90 days
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Operative details
including blood transfusion, vascular resection, number of resected lymph nodes
Time frame: intraoperative
R0 resection
defined as tumor-free margins in all the reported surgical margins (biliary and circumferential margins)
Time frame: intraoperative
Intraoperative blood loss
recorded by the anesthetist using a vacuum system
Time frame: intraoperative
Vessel reconstruction
defined as any repair or replacement of major vessels during surgery
Time frame: intraoperative