In this studly, the effects of an 12-week aerobic exercise training in persons with multiple sclerosis with restless legs syndrome will be investigated.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
30
Moderate aerobic exercise training
Dokuz Eylul University Hospital, MS Outpatient Clinic
Izmir, Turkey (Türkiye)
RECRUITINGInternational Restless Legs Syndrome Study Group rating scale for restless legs syndrome
The International Restless Legs Syndrome Study Group rating scale for restless legs syndrome is used to assess severity of the restless legs syndrome symptoms. It consists of 10 items scored by 0 to 4. Possible scores range from 0 to 40. Higher scores indicate higher severity.
Time frame: Change from Baseline at 12 weeks
Timed 25-Foot Walk
The Timed 25-Foot Walk is a quantitative mobility and leg function performance test based on a timed 25-walk. he patient is directed to one end of a clearly marked 25-foot course and is instructed to walk 25 feet as quickly as possible, but safely. The time is calculated from the initiation of the instruction to start and ends when the patient has reached the 25-foot mark. The task is immediately administered again by having the patient walk back the same distance. Patients may use assistive devices when doing this task. The score is the average of the two completed trials. Higher time represents slower walking speed and more walking impairment.
Time frame: Change from Baseline at 12 weeks
12-Item Multiple sclerosis walking scale
The 12-Item Multiple sclerosis walking scale is a self-assessment scale which measures the impact of multiple sclerosis on walking. It consists of 12 questions with Likert-type choose options concerning the limitations to walking due to multiple sclerosis during the past 2 weeks. Total score ranges 0 from 100. Higher scores indicate more impact of multiple sclerosis on walking.
Time frame: Change from Baseline at 12 weeks
Epworth Sleepiness Scale
The Epworth Sleepiness Scale is a self-administered questionnaire with 8 questions. Respondents are asked to rate, on a 4-point scale (0-3), their usual chances of dozing off or falling asleep while engaged in eight different activities. The score (the sum of 8 item scores, 0-3) can range from 0 to 24. The higher the score, the higher that person's average sleep propensity in daily life, or their 'daytime sleepiness'.
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Time frame: Change from Baseline at 12 weeks
Multiple Sclerosis International Quality of Life questionnaire
The Multiple Sclerosis International Quality of Life questionnaire is a disease-specific, self-administered, multidimensional questionnaire, was co-developed and initially validated in 15 countries including Turkey. The questionnaire comprises 31 questions in 9 subscales: activities of daily living, psychological well-being, symptoms, relationships with friends, relationships with family, sentimental and sexual life, coping, rejection, and relationships with healthcare system. All 9 dimensions and the index score were linearly transformed and standardized on a 0-100 scale, where 0 indicates the worst possible level of quality of life and 100 indicates the best level.
Time frame: Change from Baseline at 12 weeks
Pittsburgh Sleep Quality Index
Detect sleep disturbances or deficits.
Time frame: Change from Baseline at 12 weeks
Time Up and Go Test
Assessments will be performed with APDM Opals.
Time frame: Change from Baseline at 12 weeks
Six-Minute Walk Test
The 6-Minute Walk Test is a submaximal exercise test that entails measurement of distance walked over a span of 6 minutes. The goal is for the individual to walk as far and fast as possible in 6 minutes. The total distance is recorded. Higher distance represents a better submaximal exercise capacity.
Time frame: Change from Baseline at 12 weeks
Two-Minute Walk Test
Assessments will be performed with APDM Opals.
Time frame: Change from Baseline at 12 weeks
Estimated VO2 Max
Estimated VO2max will be calculated Astrand-Rhyming Cycle Ergometer Test.
Time frame: Change from Baseline at 12 weeks