Study of Inupadenant (EOS100850) With Chemotherapy as Second Line Treatment for Nonsquamous Non-small Cell Lung Cancer

Inclusion Criteria: * Confirmed diagnosis of metastatic (Stage IV) or locally advanced, unresectable (Stage III) NSCLC of nonsquamous pathology * Measurable disease as defined by RECIST v1.1 * PD-L1 expression status available at or after the time of diagnosis. All levels of expression are eligible. * Existing biopsy taken within 4 years prior to entering trial or provide fresh biopsy where safe and feasible * At least 12 weeks of treatment with only 1 anti-PD-(L)1 agent (mono or with IO combo) in the metastatic setting, OR at least 12 weeks of anti-PD-(L)1 agent (mono or with IO combo) following CRT in the unresectable, Stage III setting * ECOG performance status of 0 to 1. Exclusion Criteria: * Symptomatic central nervous system (CNS) metastases or leptomeningeal disease. * EGFR, ALK, or ROS1 mutation. * Autoimmune disease requiring systemic treatment or immunodeficiency requiring concurrent use of systemic immunosuppressants or corticosteroids * Hepatitis B or C infection unless adequately treated with no detectable viral load; Human immunodeficiency virus (HIV) unless well-controlled disease on therapy. * History of life-threatening toxicity related to prior immune therapy * Uncontrolled or significant cardiovascular disease * Pregnant or breast-feeding * Lack of agreement to use highly effective method of contraception during treatment and for 6 months after the last administration of chemotherapy