Arizona Alzheimer's Disease Research Center (ADRC)

Inclusion Criteria: * Cognitively normal persons, individuals with mild cognitive impairment or dementia who are at least 40 years of age. * Willing to undergo health and cognitive assessments, and collection and banking of blood with venipuncture for genetic research, biomarker research, and DNA banking. Exclusion Criteria: * 1\. Participants whose diagnosis is unclear and confounded by multiple possible factors are excluded. Participants with diagnoses of non-AD dementias are not excluded. 2\. Participants whose primary diagnosis is cognitive impairment due to a penetrating or single severe closed head injury, multiple sclerosis, brain tumor, metabolic or toxic encephalopathy, post-infectious (e.g., viral encephalitis, bacterial meningitis), paraneoplastic, primary psychiatric illness, or otherwise not deemed relevant to the intent of the Alzheimer Disease Center program are excluded. 3\. Procedure specific exclusion criteria also apply but this does not impact the participants ability to be included in the study.