The aim of this study is to investigate the effect of oral ketone administration during and immediately after an ultramarathon. Potential changes in cognitive function (reaction time, number of errors), running performance, jump height, skeletal muscle inflammatory infiltration and hormonal alterations will be the main focus. In this context, subjects (n=24) will perform a 100km ultrarunning trail, while receiving either ketone ester (KE, n =12) or placebo (CON, n=12). Experimental measurements will be performed immediately before and after the ultramarathon as well as 24h after the ultramarathon.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
24
Subjects receive the ketone ester at the following timepoints: 25g before ultrarun, 12.5g every 30 min during race, 25g immediately after race, 25g before sleep, 3 x 25g on day after race.
Subjects receive a non-caloric taste-matched placebo (water with sucrose octaacetate)
Exercise Physiology Research Group
Leuven, Vlaams-Brabant, Belgium
Reaction time
Change in reaction time during a reaction time task
Time frame: Before race - immediately after race
Countermovent jump
Change in countermovement jump height
Time frame: Before race - immediately after race - 48 hours after start of race
Exercise performance
Time needed to complete the ultrarun
Time frame: Immediately after race
Skeletal muscle inflammatory cell infiltration
Change in infiltration of inflammatory cells in skeletal muscle
Time frame: Before race - 48 hours after start of race
Catecholamines in blood
Change in catecholamine concentration in plasma
Time frame: Before race - immediately after race - 48 hours after start of race
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