Intralesional Injection Of Methotrexate Versus Triamcinolone Acetonid In Treatment Of Localized Psoriasis

Sohag University30 enrolled

Overview

The aim of the present study is to evaluate the efficacy of intralesional injection of methotrexate in comparison with Intralesional Injection of Triamcinolone Acetonid in localized psoriasis (body surface area \< 10%) .

study enrolling 30 patients of localized psoriasis. 15 patients received intralesional methotrexate : * Taking aseptic condition ,One psoriatic plaque will treated with Intralesional injection of methotrexate (25mg /ml) at dosage of 0.1 ml /cm2. * Another plaque will treated with intralesional ingection of distilled water as controlled plaque. * patient will receive oral folic acid 5mg tablet every day except the day of injection. Other 15 patients received intralesional trimethinolone acetonide: * Taking aseptic condition , One plaque will treated with Intralesional injection of trimethinolone acetonide (10mg/ml) at dosage of 0.1 ml/ cm2 . * another plaque will treated with Intralesional injection of distilled water as controed plaque. * Patients will take 6 sessions every 2 weeks for 3 months and will followed up at 2 month and 3 months after treatment .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Localized Psoriasis

Interventions

Intralesional Injection of MethotrexateDRUG

One psoriatic lesion will treated with Intralesional injection of methotrexate (25mg /ml) at dosage of 0.1 ml /cm Another plaque will treated with intralesional ingection of distilled water as controlled plaque. Patients will take 6 sessions every 2 weeks for 3 months and will followed up at 2 month and 3 months after treatment .

Triamcinolone AcetonidDRUG

One lesion will treated with Intralesional injection of trimethinolone acetonide (10mg/ml) at dosage of 0.1 ml/ cm2 . another plaque will treated with Intralesional injection of distilled water as controed plaque Patients will take 6 sessions every 2 weeks for 3 months and will followed up at 2 month and 3 months after treatment .

Eligibility

Sex: ALLMin age: 15 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients with localized Psoriasis (body surface area\<10%) Exclusion Criteria: * Patient refusal. Generalized psoriasis. Pregnancy. Lactation. Immunocompromised patients . Patients with history of hypersensitivity to methotrexate. Patients with other inflammatory skin disorders. Patients with chronic hepatic, renal , pulmonary ,or haematological disorders. patients on treatment for psoriasis .

Locations (1)

Sohag University

Sohag, Egypt

RECRUITING

Outcomes

Primary Outcomes

Efficacy Of Intralesional Injection Of Methotrexate Versus Triamcinolone Acetonid In Treatment Of Localized Psoriasis

clinical and dermoscopic changes according to psoriasis area severity index

Time frame: 3 months after treatment

Central Contacts

Gehad Hamdy

CONTACT

01104269431 gehad011074@med.sohag.edu.eg

Data from ClinicalTrials.gov

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