Systemic transthyretin amyloidosis is an aging-related disorder. It is usually associated with cardiac disease but also extends to other organs. Recent studies found that idiopathic carpal tunnel syndrome patients may have amyloid deposition in tenosynovial tissue. The main aims of this project are the characterization of the association between idiopathic carpal tunnel syndrome and transthyretin amyloidosis and its evaluation as a predictive factor of cardiac amyloidosis
Study Type
OBSERVATIONAL
Enrollment
100
Congo red and Immunohistochemical analysis and/or Mass spectrometry analysis
Centro Hospitalar Universitário São João
Porto, Portugal
RECRUITINGFaculty of Medicine (FMUP)
Porto, Portugal
RECRUITINGFrequency of transthyretin amyloidosis in synovial in patients with ≥60 years old
Number of patients with transthyretin amyloidosis in synovial in relation to total number of patients submitted to hand surgery
Time frame: 24 months
Association between synovial transthyretin amyloidosis with carpal tunnel syndrome
Comparison between group 1 and 2
Time frame: 24 months
Association between idiopathic carpal tunnel syndrome with cardiac transthyretin amyloidosis
Comparison between group 1 and 2
Time frame: 24 months
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