The Effect of General and Spinal Anesthesia on Neutrophil-to-lymphocyte Ratio

Antalya Training and Research Hospital60 enrolled

Overview

The aim of the study was to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients undergoing cesarean section.

This study was designed to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord NLR, PLR and MPV in patients undergoing cesarean section. The primary endpoint was to compare the effects of general and spinal anesthesia on umbilical cord NLR. Secondary endpoints were determined the general and spinal anesthesia on routine umbilical cord PLR, MPV and newborn Apgar scores at 1st and 5th min.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Anesthesia, General Anesthesia, Spinal Umbilical Cord

Interventions

General anesthesiaOTHER

Evaluate the effects of general anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Spinal anesthesiaOTHER

Evaluate the effects of spinal anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 - 45 years * American Society of Anesthesiology (ASA) II-III * elective ceserean surgery Exclusion Criteria: * declining to give written informed consent * under 18 years of age or over 45 years of age * factors affecting NLR, PLR and MPV such as preeclampsia, HELLP syndrome or premature rupture of membranes * history of neurological and/or neuromucular disease * cooperation cannot be established * emergency surgery

Locations (1)

Antalya Training and Research Hospital, Department of Anesthesiology and Reanimation

Antalya, Turkey (Türkiye)

Outcomes

Primary Outcomes

neutrophil-to-lymphocyte ratio

Evaluate the effects of NLR in patients undergoing cesarean section

Time frame: within 5 minute, following delivery

Secondary Outcomes

platelet-to-lymphocyte ratio

Evaluate the effects of PLR in patients undergoing cesarean section

Time frame: within 5 minute, following delivery

mean platelet volume

Evaluate the effects of MPV in patients undergoing cesarean section

Time frame: within 5 minute, following delivery

Newborn Apgar score 1st minute

Appearance (skin color), Pulse (heart rate), Grimace (reflex irritability), Activity (tone), Respiration. Apgar score at 1st min (0-3: severely depressed, 4-6: moderately depressed, 7-10: excellent condition)

Time frame: 1st minute after birth

Newborn Apgar score 5th minute

Time frame: 5th minute after birth

Data from ClinicalTrials.gov

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