The Roles of IL-9/E-cadherin and Ferroptosis in Intestinal Mucosal Barrier Injury in Sepsis

Nanjing First Hospital, Nanjing Medical University100 enrolled

Overview

The investigators aim to evaluate the roles of IL-9/E-cadheirin and ferroptosis in the intestinal mucosal barrier injury of sepsis. The results of this study would lay the foundation for revealing the mechanisms of EEN improving immune imbalance of sepsis and provide a new idea to the early treatment of sepsis.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Sepsis Intestinal Mucosal Barrier Ferroptosis

Interventions

Standard treatments for sepsisPROCEDURE

Standard treatments for others

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Clinical diagnosis of sepsis 2. Within 3 days of sepsis onset before ICU admission 3. No artificial nutrition (enteral or parenteral nutrition) were provided before ICU admission Exclusion Criteria: 1. Ileus 2. Digestive tract hemorrhage 3. Inflammatory bowel disease 4. Cancer or chronic organ dysfunction (e.g., hepatic or renal dysfunction) 5. Malnutrition or immunodeficiency 6. Long-term use of hormones

Locations (1)

Nanjing First Hospital

Nanjing, Jiangsu, China

RECRUITING

Outcomes

Primary Outcomes

Incidence of intestinal barrier injury incidence of intestinal barrier injury

intestinal barrier injury

Time frame: 7 days

Secondary Outcomes

Incidence of ferroptosis

ferroptosis

Time frame: 7 days

Central Contacts

Jie Zhou, Dr.

CONTACT

+8613913893984 565219791@qq.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.