This study will assess absorption, metabolism, and excretion of Radioactively Labeled Etrumadenant in healthy volunteers.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
8
Administered as specified in the treatment arm.
PRA Health Sciences (PRA) - Early Development Services (EDS)
Groningen, NZ, Netherlands
Excretion of total radioactivity in urine
Time frame: Up to 25 days
Excretion of total radioactivity in feces
Time frame: Up to 25 days
Percentage of total radioactivity in urine at selected time points
Time frame: Up to 25 days
Percentage of total radioactivity in feces at selected time points
Time frame: Up to 25 days
Mass balance recovery of total radioactivity in urine
Time frame: Up to 25 days
Mass balance recovery of total radioactivy in feces
Time frame: Up to 25 days
Number of Participants with Treatment Emergent Adverse Events (TEAEs)
Time frame: Up to 38 days
Number of participants with abnormal electrocardiogram (ECG) readings, abnormal vital signs, abnormal physical examinations and abnormal clinical laboratory tests results
Time frame: Up to 38 days
Percentage of total radioactivity in blood
Time frame: Up to 24 days
Percentage of total radioactivity in plasma
Time frame: Up to 24 days
Maximum Observed Plasma Concentration (Cmax)
Time frame: Up to 25 days
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Time to Cmax (Tmax)
Time frame: Up to 25 days
Area Under the Curve From 0 to Last Observed Non-zero Concentration (AUC [0-Last])
Time frame: Up to 25 days
Area Under the Curve From Time '0' Extrapolated to Infinity (AUC[0-inf])
Time frame: Up to 25 days
Elimination Half-life (t1/2)
Time frame: Up to 25 days