Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment

Icahn School of Medicine at Mount Sinai36 enrolled

Overview

The purpose of this research study is to investigate the relationship between light, the thickness of the pigment at the back of your eye, melatonin levels, and memory. The study will investigate whether changing light distribution pattern from "on-axis"' (i.e., directed along the eye's visual axis to the fovea) to "off-axis" (i.e., directed on the periphery of the eye's visual axis) impact melatonin suppression in 24 mild cognitive impairment participants and 24 healthy, age-matched controls.

Eligible enrolled subjects will be exposed to 4 different lighting conditions in addition to one dark control condition. There will be 5 study session and each one will last for 90 minutes and will be separated by one week. Subjects will collect 3 saliva samples, each one 30 minutes apart for melatonin levels during each study session.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Mild Cognitive Impairment Alzheimer Disease

Interventions

Lighting Intervention Blue lightDEVICE

Custom made lighting fixture that will deliver the blue lighting intervention. Blue light (λmax = 451 nm) on axis and off axis.

Lighting Intervention Green lightDEVICE

Custom made lighting fixture that will deliver the green lighting intervention. Green light (λmax = 522 nm) on and off axis

Dim-light control conditionOTHER

(\< 5 lux at the eye) for 30 min

Eligibility

Sex: ALLMin age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * mild cognitive impairment * age matched healthy control * macular pigment density either \< 0.3 or \> 0.5 Exclusion Criteria: * extensive brain vascular disease * Parkinson's disease * bipolar disorder * seasonal depression * diabetes * high blood pressure * obstructing cataracts * macular degeneration * diabetic retinopathy * use of melatonin supplements * use of beta blockers * use of sleep medications * use of antidepressant medication

Locations (1)

Light and Health Research Center at Mount Sinai

Menands, New York, United States

Outcomes

Primary Outcomes

Melatonin Levels

Saliva samples collected for melatonin levels for the different conditions. Blue light (λmax = 451 nm) on axis and off axis: for each narrowband source, designated on-axis or off-axis, will have distinct lighting distribution patterns but calibrated to deliver the same targeted levels of circadian light (CLA) and circadian stimulus (CS) at the eye. Green light (λmax = 522 nm) on and off axis: for each narrowband source, designated on-axis or off-axis, will have distinct lighting distribution patterns but calibrated to deliver the same targeted levels of circadian light (CLA) and circadian stimulus (CS) at the eye. Dim-light control condition: (\< 5 lux at the eye) for 30 min

Time frame: post-intervention (60 minutes) on each night of intervention (one night a week for 5 weeks)

Data from ClinicalTrials.gov

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