The aim of the present study is formulation and production of sachets containing macronutrients and micronutrients to enrich food at home and evaluate its effectiveness on pregnant mothers and children aged 6 to 60 months living in Sistan and Baluchestan province
This study is conducted in three steps. At first, fortification sachets are formulated and produced in accordance with international recommendations for micronutrients (vitamins A, D, zinc, and iron) and macronutrients for use in normal home conditions. In the second step, efficacy of fortified sachets are evaluate in three subgroups including pregnant mothers, 6-24 months and 2-5 years old children. Nutritional, anthropometrical and biochemical indices are evaluated at the beginning and after 6-9 months intervention. At the third step, costs and cost-effectiveness of the intervention in each of the studied groups in comparison with the usual program for that age group in the health care system of the country is determined.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
20
Every subject receives daily fortified sachets containing micro-and macronutrients for 6-9 months
Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute (NNFTRI) and Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Tehran, Iran
Weight gain during pregnancy
Weight difference at the beginning and end of pregnancy
Time frame: 6-9 months
Birth weight
Measured weight (kg) at the first day of life
Time frame: 6-9 months
Weight for age
Measured weight (kg) in a specific age (year)
Time frame: 6-9 months
Weight for height
The ratio of weight (kg) to height(m)
Time frame: 6-9 months
25-hydroxyvitamin D (nmol/L)
Fasting serum 25-hydroxyvitamin D level
Time frame: 6-9 months
Hemoglobin (g/dL)
Blood hemoglobin level
Time frame: 6-9 months
Serum ferritin (ng/mL)
Fasting serum ferritin level
Time frame: 6-9 months
Serum zinc (microg/dL)
Fasting serum zinc level
Time frame: 6-9 month
Serum retinol (micromol/L)
Fasting serum retinol level
Time frame: 6-9 months
Serum folate (ng/mL)
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Fasting serum folate level
Time frame: 6-9 months
Serum B12 (pg/mL)
Fasting serum B12 level
Time frame: 6-9 months
Apgar score
The Apgar score is a quick evaluation of one minute and five minutes after birth which tests the birthing process and readiness of newborn to meet the world without additional medical assistance
Time frame: 6-9 months