Evaluation of the Dexmedetomidine Transdermal Systems for Postoperative Analgesia Following Abdominoplasty

Inclusion Criteria: * Male or female, ≥ 18 years of age. * Scheduled to undergo a full abdominoplasty (including repair of small incidental abdominal hernias, but not including liposuction). * Have a physical status classification of 1 or 2 per the American Society of Anesthesiology. * Have a body weight \> 58 kg, and body mass index of 20 to 38 kg/m2, inclusive. Exclusion Criteria: * Known sensitivity to dexmedetomidine or any excipient in the DMTS/placebo or to any peri- or postoperative medication whose use is required in this study. * Skin abnormality (eg, scar, tattoo) or unhealthy skin condition (eg, burns, wounds) at the DMTS/matching placebo application site, according to examination by the investigator at screening or admission to the clinic prior to surgery. * History of deep vein thrombosis or factor V Leiden deficiency. * History of syncope or other syncopal attacks. * Present and/or significant history of postural hypotension (determined through examination by the investigator or designee), or history of severe dizziness or fainting on standing in the opinion of the investigator. * Evidence of a clinically significant 12-lead ECG abnormality.