This project aims to investigate cardiac function in patients with cirrhosis in the acute setting. Acute decompensation and acute-on-chronic liver failure are major events in the life of a patient as they herald disease progression and negative prognosis. Cardiocirculatory function will be assessed by serial assessments in patients admitted for acute decompensation of cirrhosis.
In this project we aim to investigate the dynamic role of cardiac function in the short-term evolution of patients with AD of cirrhosis through noninvasive and accessible tests and validate prognostic imaging and serum biomarkers. The main objectives are: 1. To describe changes and evolution of cardiac function in AD of cirrhosis 2. To investigate associations between echocardiographic parameters and serum biomarkers 3. To investigate the association between ACLF and cardiac dysfunction 4. To assess the short-term prognostic impact of cardiac function in AD and ACLF; 5. To evaluate the added predictive value of cardiac markers to current scores (CLIF-C).
Study Type
OBSERVATIONAL
Enrollment
70
Spitalul clinic Colentina
Bucharest, Romania
cardiac dysfunction
rate of onset and evolution of systolic/ diastolic dysfunction in acute decompensation
Time frame: 90 days
composite outcome
risk of developing ACLF, disease worsening, or death during follow-up
Time frame: 90 days
biomarkers
detecting biomarkers predictive for cardiac dysfunction and disease severity
Time frame: 30 days
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