In this prospective randomized controlled trial, the subjects will be assigned to group transcutaneous electrical acupoint stimulation (TEAS) and group control (no intervention). The postoperative outcomes including NIHSS (National Institute of Health stroke scale) score, morbidity and mortality will be evaluated during hospital stay and by one year after surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
158
Electrodes are placed at acupoints and connected to the stimulator. Electrical stimulation is given during surgery.
Xijing hospital, Fourth military medical university
Xi'an, Shaanxi, China
RECRUITINGnumber of patients with major in-hospital postoperative complications
major complications include myocardial infarction, heart failure, respiratory failure, mechanical ventilation, cerebral infarction, delirium and coma
Time frame: from end of surgery to discharge from hospital, in an average of 7 days
mortality by 30 days after surgery
Time frame: from end of surgery to 30 days after surgery, in a total of 30 days
mortality by 3 months after surgery
Time frame: from end of surgery to 3 months after surgery, in a total of 3 months
number of patients with major postoperative complications by 3 months after surgery
major complications include myocardial infarction, heart failure, respiratory failure, mechanical ventilation, cerebral infarction, delirium and coma
Time frame: from end of surgery to 3 months after surgery, in a total of 3 months
mortality by 6 months after surgery
Time frame: from end of surgery to 6 months after surgery, in a total of 6 months
number of patients with major postoperative complications by 6 months after surgery
major complications include myocardial infarction, heart failure, respiratory failure, mechanical ventilation, cerebral infarction, delirium and coma
Time frame: from end of surgery to 6 months after surgery, in a total of 6 months
duration of postoperative in-hospital stay
Time frame: from end of surgery to discharge from hospital, in an average of 7 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
serum interleukin-6 level at the end of the surgery
Time frame: at end of the surgery
serum tumor necrosis factor-α level at the end of the surgery
Time frame: at end of the surgery
episodes of hypotension during surgery
hypotension is defined as mean arterial pressure decreased by more than 20% of the baseline and persisting more than 1 minute
Time frame: from start of surgery to end of surgery, in an average of 2 hours
Score of Mini-mental State Examination at 1 day after surgery
A Mini-Mental State Examination (MMSE) is a set of 30 questions that doctors and other healthcare professionals commonly use to check for cognitive impairment (problems with thinking, communication, understanding and memory). MMSE is with a maximal score of 30. A higher score means better cognitive function.
Time frame: at 24h after the end of surgery
Score of Mini-mental State Examination at 3 days after surgery
A Mini-Mental State Examination (MMSE) is a set of 30 questions that doctors and other healthcare professionals commonly use to check for cognitive impairment (problems with thinking, communication, understanding and memory). MMSE is with a maximal score of 30. A higher score means better cognitive function.
Time frame: at 72h after the end of surgery
visual analog scale of pain at 1 day after surgery
visual analogue scale is a scale of 10cm, 0 is for no pain, 10 is for pain that can not be tolerated. The participant is asked to mark the scale of their pain
Time frame: at 24h after the end of surgery
visual analog scale of pain at 3 days after surgery
visual analogue scale is a scale of 10cm, 0 is for no pain, 10 is for pain that can not be tolerated. The participant is asked to mark the scale of their pain
Time frame: at 72h after the end of surgery
Quality of recovery score at 3 days after surgery
Quality of recovery-40 is a questionnaire consisted of 40 questions about the recovery of the patient. Higher score means better recovery.
Time frame: at 72h after the end of surgery
Rankin's score at 3 days after surgery
Rankin's score consists of class of 6 levels and is used for evaluation of neurologic function. Higher score means worse outcome.
Time frame: at 72h after the end of surgery