Anatomical Variation of Cerebral Venous Sinus in Healthy Individuals

Capital Medical University40 enrolled

Overview

The anatomical characteristics of veins and venous sinus result in great differences between cerebral venous system diseases and cerebral artery diseases in etiology, pathophysiology and clinical features.Therefore, understanding the anatomy and variation of normal venous sinuses is essential to identify the intracranial venous lesions.

The classification of venous sinus and its variation based on the autopsy of patients can not fully reflect the real anatomy and variation of venous sinus in human, and the targeted research on healthy people is still unknown. The main purpose of this research is to use multimodal magnetic resonance technology to study the variation of venous sinus in Chinese healthy population, to preliminarily improve the anatomical classification of venous sinus in Chinese , to verify the the correlation between venous sinus variation and various non-genetic factors at the same time, as well as establishing reliable quantitative evaluation indicators.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Venous Sinus Thrombosis, Cranial

Interventions

anotomy and variation of venous sinusDIAGNOSTIC_TEST

Contrast enhanced-magnatic resonance venography（CE-MRV）and other magnetic resonance imaging methods are used to estimate the anatomy of cerebral venous sinus.

the level of biomarker in boodDIAGNOSTIC_TEST

Elisa or omics analysis is used to test the level of biomarker in blood.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 18 - 35 years old. 2. Confirmed no intracranial diseases, congenital abnormalities such as intracranial hematoma, tumor, vascular malformation, hydrocephalus, etc. 3. Voluntarily signed informed consent. Exclusion Criteria: 1. Any clinical history, including hypertension, diabetes, coronary heart disease, hematologic and rheumatic immune system diseases,cervical spondylosis, anxiety, depression, insomnia, etc. 2. Internal jugular venous outflow disturbance : MRV from extracranial to aortic arch demonstrates variation or stenosis of the internal jugular vein, vertebral plexus, brachiocephalic vein, and superior vena cava. 3. Any history of craniocerebral trauma or surgery that affected the existence and running of veins.Unhealthy habits such as smoking, heavy drinking, etc. 4. Women who are pregnant or in preparation for pregnancy or lactation. 5. Other conditions that the researchers considered might affect the trial and inappropriate for inclusion.

Locations (1)

Xuanwu hospital;Capital Medical University

Beijin, XI Cheng District, China

RECRUITING

Outcomes

Primary Outcomes

The anotomy and variation of venous sinus in Chinese healthy individuals

According to the connection types of superior sagittal sinus and transverse sinus at the the torcular Herophili assessed with contrast-enhanced MR venography and phase-contrast MR venography, describe the anatomical classification of venous sinus based on the anatomical descriptions of Osborn and describe the anatomical variations that are not included in the existing classification. Calculating the proportion of each type.

Time frame: On the day of examination

Secondary Outcomes

The diameters of venous sinus and small veins in Chinese healthy individuals

Measuring the diameters of venous sinus and small veins assessed with contrast-enhanced MR venography

Time frame: On the day of examination

Serum biomarkers in Chinese healthy individuals

The level of biomarkers are detected using Elisa or omics analysis

Time frame: On the day of examination

Central Contacts

Xunming Ji, MD.PhD

CONTACT

010-83199430 jixm@ccmu.edu.cn

Lu Liu, MD

CONTACT

13370186128 bingtangjiaozi@163.com

Data from ClinicalTrials.gov

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