In a previous study, 24 volunteers consumed two conventional eggs or two eggs naturally enriched with omega 3, 5 and 7 every day for 3 months. It was shown that these eggs were well tolerated and that the omega enrichment led to a reduction in waist circumference of 3 cm in 3 months. The objective of Omegasnack study was therefore to go further in the evaluation of these effects on waist circumference; 1) confirm the effects of these eggs on waist circumference when included in a snack, 2) determine whether this reduction in waist circumference is linked to a reduction in muscle and/or fat mass (subcutaneous and/or visceral) and 3) evaluate whether these effects are associated with a modification in the accumulation of ectopic fat in the muscle and/or liver.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
24
Control group ate snacks composed of dried vegetables, one classical egg yolk and 2.3g of sunflower oil during 10 weeks
Tes group ate snacks composed of dried vegetables, one test egg yolk naturally enriched in rumenic acid, docosahexaenoic acid and punicic acid, 0.34g of pomegranate seed oil and 2.26g of olive oil during 10 weeks
UCLouvain - CICN
Louvain-la-Neuve, Belgium
Change from baseline of waist circumference at 10 weeks
Time frame: Baseline, 10 weeks
Change from baseline of waist circumference at 5 weeks
Time frame: Baseline, 5 weeks
Satiety
Visual analog scale (between 0 = no satiety to 100 = complete satiety)
Time frame: Baseline, 5 weeks, 10 weeks
Red blood cells fatty acid pattern
Time frame: Baseline, 5 weeks, 10 weeks
Plasma fatty acid pattern
Time frame: Baseline, 5 weeks, 10 weeks
Plasma triglyceride
Time frame: Baseline, 5 weeks, 10 weeks
Plasma LDL cholesterol
Time frame: Baseline, 5 weeks, 10 weeks
Plasma total cholesterol
Time frame: Baseline, 5 weeks, 10 weeks
Plasma HDL cholesterol
Time frame: Baseline, 5 weeks, 10 weeks
Plasma non-HDL cholesterol
Time frame: Baseline, 5 weeks, 10 weeks
Glycemia
Time frame: Baseline, 5 weeks, 10 weeks
Insulinemia
Time frame: Baseline, 5 weeks, 10 weeks
HOMA (Homeostatic Model Assessment for Insulin Resistance)
Time frame: Baseline, 5 weeks, 10 weeks
QUICKI
Time frame: Baseline, 5 weeks, 10 weeks
Body weight
Time frame: Baseline, 5 weeks, 10 weeks
Impedancemeter lean mass
Time frame: Baseline, 5 weeks, 10 weeks
Impedancemeter fat mass
Time frame: Baseline, 5 weeks, 10 weeks
Hip circumference
Time frame: Baseline, 5 weeks, 10 weeks
CRP (c-reactive protein)
Time frame: Baseline,10 weeks
Oxidized LDL
Time frame: Baseline,10 weeks
Endothelial status
HbNO (hemoglobin-NO adduct)
Time frame: Baseline,10 weeks
Liver stiffness
Transient elastography
Time frame: Baseline,10 weeks
Liver steatosis
Controlled attenuation parameter (CAP)
Time frame: Baseline,10 weeks
Subcutaneous fat area evaluated by computed tomography (CT) scan
Time frame: Baseline,10 weeks
Visceral fat area evaluated by computed tomography (CT) scan
Time frame: Baseline,10 weeks
Skeletal muscle index (total skeletal muscle area normalized for stature) evaluated by computed tomography (CT) scan
Time frame: Baseline,10 weeks
Muscular radiation attenuation (fat accumulation in muscle) evaluated by computed tomography (CT) scan
Time frame: Baseline,10 weeks
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