Effect of S-ketamine in Cesarean Section Combined Anesthesia

The Second Affiliated Hospital of Chongqing Medical University120 enrolled

Overview

To compare the anti-hyperalgesia effect between S-ketamine with placebo for Maternal receiving elective Cesarean Section under Combined spinal and epidural analgesia. Based on this study the investigators intend to verify the role and potential mechanism of S-ketamine combined anesthesia in alleviating hyperalgesia after cesarean section, prove that it can reduce hyperalgesia and postoperative pain. explore the role of S-ketamine in alleviating postoperative hyperalgesia in different PCA ways and explore the safety of S-ketamine in the perilactation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

120

Conditions

Postoperative Pain

Interventions

S-ketamineDRUG

S-ketamine or placebo were given to the fetus after delivery Patient-controlled intravenous analgesia or patient-controlled epidural analgesia were administered postoperatively

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA status I-III * Age 20 to 45 * 37-42 weeks gestation * undergo elective cesarean section with subarachnoid anesthesia * participate in this study and sign informed consent Exclusion Criteria: * Patients with contraindications for cesarean section * Patients with contraindications of combined spinal and epidural anesthesia * Patients with severe systemic disease * Alcoholism and long-term use of anti-inflammatory and analgesic drugs * Patients who were unable to cooperate or refused to participate in the trial * Patients with contraindications to esketamine and hydromorphone

Locations (1)

Department of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University

Chongqing, Chongqing Municipality, China

Outcomes

Primary Outcomes

Maximum pain score (NRS socre) at 0-24 hours postoperatively

NRS score: Pain was assessed on a scale of 0-10, with 0 being no pain and 10 being most painful

Time frame: From ending of the surgery to 24 hours postoperatively

Pain score (NRS socre) at 0-6 hours postoperatively

NRS score: Pain was assessed on a scale of 0-10, with 0 being no pain and 10 being most painful

Time frame: From ending of the surgery to 6 hours postoperatively

Pain score (NRS socre) at 6-12 hours postoperatively

NRS score: Pain was assessed on a scale of 0-10, with 0 being no pain and 10 being most painful

Time frame: From 6 hours postoperatively to 12 hours postoperatively

Pain score (NRS socre) at 12-24 hours postoperatively

NRS score: Pain was assessed on a scale of 0-10, with 0 being no pain and 10 being most painful

Time frame: From 12 hours postoperatively to 24 hours postoperatively

Secondary Outcomes

The number of patient controlled analgesia pump pressed

When the patients felt pain, the patient controlled analgesia pump can be pressed once

Time frame: 0-48 hours postoperatively

Patient controlled analgesia pump analgesic consumption

The amount of the analgesic consumption

Time frame: 0-48 hours postoperatively

Pressure pain threshold at 30min after surgery

Pressure pain threshold was measured using pressure manometer in the forearm of dominant hand reported by kg/cm2

Data from ClinicalTrials.gov

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