It is important for clinicians to maintain and support for exercise capacity and quality of life of lung cancer patients after radiation therapy, because radiation therapy also affect the lung function and general conditions of patients. The effect and safety of pulmonary rehabilitation is well-proven in various diseases. Because there is no standard treatment, the investigators will perform this study to clearly prove the effect of pulmonary rehabilitation in lung cancer patients receiving radiation therapy.
Roles of the radiation therapy in lung cancer are as followings; 1) to treat the lung caner stage 1 \~2 patients, who are inadequate for operation due to declined lung function, 2) to treat the locally advanced and inoperable stage 3 patients with concurrent chemotherapy, and 3) to palliatively treat the stage 4 patient. However, it is also possible that radiation therapy worsens the general weakness and lung function, although the degree of deterioration was generally less than lung resection. Therefore, it is crucial for clinicians to maintain and support for exercise capacity and quality of life of lung cancer patients after radiation therapy. The effect and safety of pulmonary rehabilitation is well-proven in various diseases. Investigators presented a retrospective study about the effect of pulmonary rehabilitation in patients receiving radiation therapy, which showed less decreased lung function, less radiation related pneumonitis, and decreased mortality. Investigators will perform this study to clearly prove the effect of pulmonary rehabilitation in lung cancer patients receiving radiation therapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
70
Pulmonary rehabilitation runs for 60 minutes per session. The pulmonary rehabilitation program is based on a comprehensive approach, not simply providing regular exercise. And it includes patient education, active encouragement, and psychological support by investigators. Exercise is performed more than twice a week. Each session is performed for 60 minutes and includes breathing exercises, low to medium-intensity aerobic exercises, and muscle exercises under the guidance of a investigator. After radiation therapy is completed, investigators will recommend that patients perform pulmonary rehabilitation at home more than twice a week and for 60 minutes or more. The patients will record whether and when exercise is performed every day in the diary for pulmonary rehabilitation.
Asan Medical Center, University of Ulsan College of Medicine
Seoul, Songpa, South Korea
Change of 6 minutes walking test at 7 months
Change of walking distance from baseline 6 minutes walking test at 7 months
Time frame: 7 months
All cause mortality
All cause mortality during study periods
Time frame: From the initiation of radiation therapy to 7 months at end of radiation therapy
Radiation therapy related pneumonitis
Radiation therapy related pneumonitis requiring steroid therapy
Time frame: From the initiation of radiation therapy to 7 months at end of radiation therapy
Forced Expiratory Volume in 1 sec at 7 months
Forced Expiratory Volume in 1 sec (L, predicted percentage) at 7 months
Time frame: 7 months
Forced Expiratory Volume in 1 sec at 1 month
Forced Expiratory Volume in 1 sec (L, predicted percentage) at 1 month
Time frame: 1 month
Forced Vital Capacity at 7 months
Forced Vital Capacity (L, predicted percentage) at 7 months
Time frame: 7 months
Forced Vital Capacity at 1 month
Forced Vital Capacity (L, predicted percentage) at 1 month
Time frame: 1 month
Carbon monoxide diffusing capacity at 7 months
Carbon monoxide diffusing capacity (mL/mmHg/min, predicted percentage) at 7 months
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Time frame: 7 months
Carbon monoxide diffusing capacity at 1 month
Carbon monoxide diffusing capacity (mL/mmHg/min, predicted percentage) at 1 month
Time frame: 1 month
Change of dyspnea scale at 7 months
Investigators will measure the change from the baseline Modified Medical Research Council Dyspnea Scale in the range of 0 to 4, which means the higher the result, the more severe the degree of dyspnea
Time frame: 7 months
Change of dyspnea scale at 1 month
Investigators will measure the change from the baseline Modified Medical Research Council Dyspnea Scale in the range of 0 to 4, which means the higher the result, the more severe the degree of dyspnea
Time frame: 1 month
Grip strength at 7 months
Grip strength will be measured by digital group hand dynamometer
Time frame: 7 months
Grip strength at 1 month
Grip strength will be measured by digital group hand dynamometer
Time frame: 1 month
Maximal inspiratory pressure at 7 months
To evaluated respiratory muscle strength, investigators will measure maximal inspiratory pressure by portable spirometry
Time frame: 7 months
Maximal expiratory pressure at 7 months
To evaluated respiratory muscle strength, investigators will measure maximal expiratory pressure by portable spirometry
Time frame: 7 months
Maximal inspiratory pressure at 1 month
To evaluated respiratory muscle strength, investigators will measure maximal inspiratory pressure by portable spirometry
Time frame: 1 month
Maximal expiratory pressure at 1 month
To evaluated respiratory muscle strength, investigators will measure maximal expiratory pressure by portable spirometry
Time frame: 1 month
Skeletal muscle mass at 7 months
Investigators will measure the skeletal muscle mass by bioimpedance
Time frame: 7 months
Skeletal muscle mass at 1 month
Investigators will measure the skeletal muscle mass by bioimpedance
Time frame: 1 month
Appendicular muscle mass at 1 month
Investigators will measure the appendicular muscle mass by bioimpedance
Time frame: 1 month
Appendicular muscle mass at 7 months
Investigators will measure the appendicular muscle mass by bioimpedance
Time frame: 7 months
Change of The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Lung Cancer 13 at 7 months
Investigators will assess change from the baseline quality of life of patients by questionnaire (The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Lung Cancer 13) at 7 months. (the higher values indicate a greater degree of symptoms, min.: 0, max.: 100)
Time frame: 7 months
Change of The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 at 7 months
Investigators will assess change from the baseline quality of life of patients by questionnaire (The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30) at 7 months. (the higher values indicate a greater degree of symptoms, min.: 0, max.: 100)
Time frame: 7 months
Change of The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Lung Cancer 13 at 1 month
Investigators will assess change from the baseline quality of life of patients by questionnaire (The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Lung Cancer 13) at 1 month. (the higher values indicate a greater degree of symptoms, min.: 0, max.: 100)
Time frame: 1 month
Change of The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 at 1 month
Investigators will assess change from the baseline quality of life of patients by questionnaire (The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30) at 1 month. (the higher values indicate a greater degree of symptoms, min.: 0, max.: 100)
Time frame: 1 month
Change of 6 minutes walking test at 1 month
Change of walking distance from baseline 6 minutes walking test at 1 month
Time frame: 1 month