Analyzing the Relationship Between Speed Propofol is Given and Low Blood Pressure

University of Toledo100 enrolled

Overview

The objective of this study is to evaluate the hemodynamic changes related to Propofol administration rate. We hypothesize that slow administration of IV propofol will have less hemodynamic disturbances and will require less amount of vasoactive medication for BP correction when compared to standard FDA approved administration rate.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

100

Conditions

Hypotension on Induction

Interventions

Propofol slow administrationOTHER

Propofol will be slowly administered over 120 seconds by anesthesia provider

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * any patient from 18 till 80 years of age * patient undergoing non-cardiac elective surgery * duration of the surgery longer than one hour * native/fluent English speaker * patients whose staff anesthesiologist planned to use Propofol as a primary anesthetic for induction Exclusion Criteria: * any patient admitted for non-elective surgery * any patient undergoing cardiac surgery * any patient under 18 years of age * any patient older than 80 years of age * any patient with history of severe heart disease (CHF with significant limitations of activity due to sever symptoms, prior heart surgery, atrial fibrillation, etc.) * any patient with pre-operative hemodynamic instability (e.g. sepsis, chronic kidney disease, liver cirrhosis) who requires constant or intermittent administration of vasoactive or inotropic medication to support vital signs (BP) * any patient on vasoactive or inotrop medications in early pre-operative period (within 24 hours prior to the surgery) * any patient who does not speak English or not fluently * any patient with cognitive impairment or mentally incapacitation * any pregnant or breastfeeding females * any patient whose staff anesthesiologist planned to use a primary anesthetic other than Propofol

Locations (1)

The University of Toledo Medical Center

Toledo, Ohio, United States

Outcomes

Primary Outcomes

Patients Administered Propofol at a Slower Rate of Infusion Will Have Lower Incidence of Post Induction Hypotension Than Patients Administered Propofol at FDA Approved Rate.

We will collect the patient's blood pressure intra-operatively every 5 minutes starting on induction up to one hour after induction and compare.

Time frame: induction to 1 hour post induction

Secondary Outcomes

Patients Administered Propofol at a Slower Rate Will Have Less Complications During the Early Post-op Period Than Patients Administered Propofol at FDA Approved Rate.

We will collect the patient's blood pressure post-operatively and length of hospital stay and compare.

Time frame: immediate post-op to 30 days post operatively

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.