This study aims to assess the feasibility of performing neuropsychological testing to measure the cognitive performance of individuals following Axicabtagene ciloleucel CAR-T therapy at Stanford.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Upon completion of the consent, the subject will be booked into an available 90 minute in-person or remote neuropsychological testing
Stanford Cancer Center
San Francisco, California, United States
Number of patients who complete neuropsychological testing in the post-CAR-T adult population
Time frame: 6 months
Number of patients who complete telehealth neuropsychological testing in the post-CAR-T adult
Time frame: 6 months
Wechsler Test of Adult Reading WTAR Neuropsychological testing
The neuropsychological testing will capture any potential deficits in language, processing speed, executive functioning and visuospatial abilities, and may be compared to age and education-matched normative data.
Time frame: Baseline
Hopkins Verbal Learning Test HVLT
The neuropsychological testing will capture any potential deficits in language, processing speed, executive functioning and visuospatial abilities, and may be compared to age and education-matched normative data.
Time frame: Baseline
Controlled Oral Work Association Test COWAT
The neuropsychological testing will capture any potential deficits in language, processing speed, executive functioning and visuospatial abilities, and may be compared to age and education-matched normative data.
Time frame: Baseline
Trails A and B (Oral Trails)
The neuropsychological testing will capture any potential deficits in language, processing speed, executive functioning and visuospatial abilities, and may be compared to age and education-matched normative data.
Time frame: Baseline
Digit Span
The neuropsychological testing will capture any potential deficits in language, processing speed, executive functioning and visuospatial abilities, and may be compared to age and education-matched normative data.
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Time frame: Baseline
Clock Drawing Test
The neuropsychological testing will capture any potential deficits in language, processing speed, executive functioning and visuospatial abilities, and may be compared to age and education-matched normative data.
Time frame: Baseline
Short form of Quality of Life SF-36
Items from the SF36 (Short Form 36) survey
Time frame: Baseline
General Anxiety Disorder Assessment GAD-7
Assesses anxiety symptoms The following cut-offs correlate with level of anxiety severity: Score 0-4: Minimal Anxiety, Score 5-9: Mild Anxiety, Score 10-14: Moderate Anxiety, Score greater than 15: Severe Anxiety
Time frame: Baseline
Patient Health Questionnaire PHQ9
Assesses depressive symptoms PHQ-9 Score 0 - 4 None, Mild= 5 - 9 , Moderate=10 - 14 , Moderately Severe=15 - 19 , Severe=20 - 27
Time frame: Baseline