Observation of the Natural Course of Age-related Macular Degeneration

Inclusion Criteria: * 50-85 yrs male or female AMD patients * Dry-AMD patients in either early, intermediate, or intermediate-to-late stage confirmed by fundus examinations. Exclusion Criteria: * Any eye with disease that would interfere with the retinal examinations * Research eye with CNV or high myopia * Surgeries that may interfere with AMD evaluation * Long-term uses of medications that are associated with retinal or neural toxicities. * IOP more than 26 mmHg * Received cataract surgery in 3 months. * Other conditions: diseases that causes less than 5 years survival; any condition that causes high risk of drop-out, or low compliance, for instance cognition disorder; have been involved in other trial that interfere with the current visit plan; taking other angiogenesis Inhibitors drugs for treating cancer. * Other conditions not suitable for the current study