Induction Chemotherapy and Toripalimab Followed by Radiotherapy in Unresectable Laryngeal/Hypopharyngeal Carcinoma

Inclusion Criteria: * Pathologically confirmed, unresectable locally advanced laryngeal/hypopharyngeal squamous cell carcinoma due to extensively local invasion or medical comorbidities (T3-4b, N0-N3, M0); * Age between 18-75 years; * Signed inform consent; * Had at least one measurable lesion according to RECIST 1.1 criteria * Anticipated overall survival more than 3 months; * Satisfactory performance status: ECOG (Eastern Cooperative Oncology Group) scale 0-1; * Normal organ function and bone marrow function; * HBV DNA\<500 IU/mL（or 2500 copies/mL）and HCV RNA negative ; * Male and no pregnant female, able to adapt birth control methods during treatment. Exclusion Criteria: * Hypersensitivity to Toripalimab, Paclitaxel or Cisplatin; * Suffered from malignant tumors, except cervical carcinoma in situ, papillary thyroid carcinoma, or skin cancer (non- melanoma) within five years; * Severe, uncontrolled heart disease; * Receive vaccine or live vaccine within 28 days prior to signing the informed consent; * Equivalent dose more than prednisone 10mg/d or other immunosuppressive treatments within 28 days prior to signing the informed consent; * Surgery or trauma within 28 days prior to signing the informed consent; * Received other immune checkpoint inhibitors previously; * Severe, uncontrolled infections within 28 days of prior to signing the informed consent; * Active, known or suspected autoimmune disease; Type I Diabetes, hypothyroidism those only need hormone replacement therapy, vitiligo or inactive asthma who don't need systemic therapy can recruit; * History of interstitial lung disease; * HIV positive; * Hepatitis B surface antigen (HBsAg) positive and HBV-DNA ≥500IU/ml, or 2500cps/ml; Positive HCV RNA; * Other diseases which may influence the safety or compliance of the clinical trial, such as mental illness, or their family and society factors; * Women of child-bearing potential who are pregnant or breastfeeding.