Early Goal-Directed Therapy Utilizing Transpulmonary Thermodilution and Severe Burn Injury

N/ACompletedNCT05420610

Chang Gung Memorial Hospital66 enrolled

Overview

This study aimed to optimize fluid resuscitation with transpulmonary thermodilution (TPTD)-guided protocol and to lower the mortality rate of the severely burned.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Burns

Interventions

Control group: Patients being admitted when The advancement of transpulmonary thermodilution(TPTD) device was unavailable.OTHER

The control group included patients being admitted when TPTD device was unavailable; and relatively stable patients without the need for TPTD. The adequacy of fluid resuscitation in the control group was monitored by traditional monitoring parameters including vital signs and hourly urine output.

Study group: TPTD device was implemented for monitoring.OTHER

TPTD device was implemented for monitoring; the inclusion criteria included patients suffering from 2nd degree burn greater than 40% TBSA; a combined 2nd to 3rd degree burn greater than 30% TBSA; or patients with inhalation injury despite the burned surface area.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients (age \> 18 years). * Major burn (as total burned surface area (TBSA) \> 20% with at least second degree burn depth). * Admitted to the intensive care unit (ICU) of the Burn Center. Exclusion Criteria: * Patients younger than 18 years old. * Patients with severe cardiopulmonary diseases, or associated with other major trauma. * Patient with incomplete data.

Locations (1)

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, Taiwan

Outcomes

Primary Outcomes

Patient mortality

The primary outcome was patient mortality after major burn.

Time frame: Up to 6 months

Data from ClinicalTrials.gov

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