Post-prandial Glycaemic Controlling Effects of BSG in Singapore Adults With Metabolic Syndrome

National University of Singapore16 enrolled

Overview

The purpose of this study is to assess the glycaemic controlling effects of BSG and bio-transformed BSG-containing biscuits in Singapore adults with MetS. The investigators hypothesized that consumption of BSG and bio-transformed BSG containing biscuit will improve glycaemic control.

This is a double-blind, randomised, crossover experiment. During the 3-week, 19 subjects will participate in a 3 meal tolerance test (MTT). During each MTT session, all subjects are required to consume 90 g biscuits (either control, autoclaved BSG or bio-transformed BSG biscuits) and monitored over a period of 240 minutes. All three types of biscuits will be consumed at a randomised sequence during this 3-week period. Post-prandial blood glucose, insulin, lipid and amino acid responses, breath analysis, body composition, blood pressure, appetite assessment, and any other glycaemic biomarkers will be assessed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Metabolic Syndrome Diabetes Diet Modification

Interventions

autoclaved BSG-containing biscuitsDIETARY_SUPPLEMENT

Consumption of autoclaved BSG-containing biscuits as breakfast.

bio-transformed BSG-containing biscuitsDIETARY_SUPPLEMENT

Consumption of bio-transformed BSG-containing biscuits as breakfast.

control biscuitsDIETARY_SUPPLEMENT

Consumption of plain biscuits as breakfast.

Eligibility

Sex: ALLMin age: 35 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male and female participants, aged 35-85 years old * English-literate and able to give informed consent in English * Willing to follow the study procedures * Meet any 3 of the 5 following NCEP-ATP III MetS criteria: waist circumference \> 102 cm (male), \> 88 cm (female) (For Asian population: Waist circumference \> 90 cm (male), \> 80 cm (female)); fasting glucose concentration ≥ 100 mg/dL or on medication; triglyceride ≥ 150 mg/dL or on medication; high density lipoprotein cholesterol (HDL) \< 40 mg/dL (male), \< 50 mg/dL (female); systolic or diastolic blood pressure \> 130/85 mmHg or on medication); Exclusion Criteria: * Significant change in weight (≥ 3 kg body weight) during the past 3 months * Allergy to barley, wheat, corn, egg, or other ingredients found inside the biscuits. * Acute illness at the study baseline * Exercising vigorously\* over the past 3 months. \*Defined as having \> 6 metabolic equivalents of exercise daily; approximately 20 mins of moderate intensity exercise (e.g. slow jogging) a day * Following any restricted diet (e.g. vegetarian) * Smoking * Have a daily intake of more than 2 alcoholic drinks per day * Taking dietary supplements or food which may impact the outcome of interests (e.g. fermented foods, probiotic supplement etc.) * Consumption of antibiotics over past 3 months. * Pregnant, lactating, or planning pregnancy in the next 6 months * Insufficient venous access to allow the blood collection * Prescribed and taking antihypertensive/cholesterol-lowering/ type-2 diabetic medication which started less than 3 years prior to the intervention participation * High current intake of fibre\* from brown rice or wholemeal products. \*High, moderate or low intake taken as ≥ 6 servings, 4 - 5 servings, and ≤ 3 servings daily respectively based on My Healthy Plate guidelines * High current intake of fibre\* from vegetables. \* High, moderate or low intake taken as ≥ 2 servings, 2 servings, and ≤ 1 serving respectively based on My Healthy Plate guidelines

Locations (1)

Yujing Xu

Singapore, Singapore