Effect of E-Liquid Flavor on Respiratory Symptoms in People Using Electronic Nicotine Delivery Systems

Inclusion Criteria: * ENDS users as determined by: (a) using banned flavored ENDS with nicotine such as fruit, candy, dessert flavors, and/or any product that indicates such flavors (b) using ENDS daily, regularly for the past 6 months (self-reported). * No smoking tobacco or using smokeless tobacco for the past 6 months. * Subjects should be free of acute respiratory illness within the proceeding 30 days prior to recruitment (self-reported). * Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure. * After receiving information regarding the NYS flavor ban individuals must not want to quit vaping or stop using their flavored product for the next 90 days. Exclusion Criteria: * Individuals with health conditions and therapies that may affect immune responses and levels of inflammatory markers, including allergic rhinitis, aspirin/NSAID therapy, asthma, immunodeficiency (HIV or other), Guillain-Barre Syndrome, COPD, or fever/respiratory illness within 30 days prior to entry into study (self-reported). * Pregnant or nursing female participants (self-reported on telephone screener, pregnancy test on Visit#1) * Unable to communicate in English. * Unable or unwilling to follow protocol requirements. * Self-report having active, untreated medical/psychiatric conditions. * History of serious side effects from nicotine or from any nicotine replacement therapies. * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Vulnerable populations, such as cognitively impaired adults, individuals who are not yet adults, pregnant women, and prisoners. * Any condition which in the Investigator's opinion deems the participant an unsuitable candidate to receive study drug. * After receiving information about the NYS flavor ban, participants who report that they are thinking about quitting or stop using their flavor within the next 90 days.