Diets, Lipoproteins and Inflammation Markers

Buddhist Tzu Chi General Hospital21 enrolled

Overview

Systematic inflammation and lipid profiles are two major therapeutic targets for cardiovascular diseases. The effectiveness of vegan diet has been reported (doi: 10.3389/fnut.2022.807810). Aim: To compare the effectiveness of a nutritionally balanced vegan diet and a Myplate diet ((Taiwanese version) on systematic inflammation and lipoprotein subclass. Design: Randomized crossover design

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Cardiovascular Diseases Metabolic Syndrome Diet, Healthy Vegan Diet Inflammatory Response

Interventions

Vegan dietBEHAVIORAL

The participants were advised to eat foods in their original type.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients with dyslipidemia (at least one of the following) * TG ≥ 150 mg/dL * TC ≥ 200 mg/dL * LDL-c≥ 130 mg/dL, * HDL-c \< 45 mg/dL for male or \< 55 mg/dL for female or receiving statin treatment Exclusion Criteria (fulfill one of the following condition): * chronic kidney disease * history of coronary artery disease * ischemic heart disease, * heart failure, * stroke, * cancer of any type

Locations (1)

Hualien Tzu Chi Hospital

Hualien City, Taiwan

Outcomes

Primary Outcomes

Novel inflammatory markers for cardiovascular disease and Lipoprotein particles concentration

GlycA (umol/L), lipoprotein particles concentration(umol/L)

Time frame: 12 weeks

Lipoprotein particles concentration

lipoprotein particles concentration (nmol/L）

Time frame: 12 weeks

lipoprotein particles size

lipoprotein particles size (nm)

Time frame: 12 weeks

Trimethylamine-N-oxide

TMAO (uM). TMAO is a low molecular weight compound that belongs to the class of amine oxides

Time frame: 12 weeks

Traditional cadiometabolic risk factors 1

TG(mg/dL), LDL-C(mg/dL), HDL-C(mg/dL), Total cholesterol(mg/dL)

Time frame: 12 weeks

Traditional cadiometabolic risk factors 2

HbA1c(%)

Time frame: 12 weeks

Traditional cadiometabolic risk factors 3

HOMA-IR index (Homeostasis Model Assessment-Insulin Resistance index)

Time frame: 12 weeks

Data from ClinicalTrials.gov

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