Electroclinical Features of Sudden Unexpected Death in Epilepsy (SUDEP) : a Multi-center Observational Study

Liu Yonghong30 enrolled

Overview

Sudden unexpected death in epilepsy (SUDEP) is regarded as a leading cause of premature death in epilepsy patients. We aim to capture the whole process of SUDEP and near-SUDEP occurrence in patients with epilepsy, and expolre video-electroencephalograph (V-EEG) changes and marker. A Chinese multicenter study was carried out to determine electroencephalo-graph marker related to SUDEP to provide a scientific basis for the prevention of SUDEP in patients with epilepsy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sudden Unexpected Death in Epilepsy Near-Sudden Unexpected Death in Epilepsy

Interventions

Video-ElectroencephalographyDIAGNOSTIC_TEST

Three types of video EEG monitoring equipment produced by Nicolet, Bio-logic and Nihon Kohden were used to collect data in the multi-center. The 19-lead recording electrode was placed according to the international 10-20 system, and the average lead was used. The recording time was 24h. All patients underwent eyes open and closed test, intermittent photic stimulation and hyperventilation induction test.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with epilepsy who meet SUDEP or near-SUDEP diagnosis, * Giving written informed consent to participate in the study from relatives or caregivers. Exclusion Criteria: * Refusing to recruitment from relatives or caregivers.

Locations (1)

Liu Yonghong

Xi'an, Shaanxi, China

Outcomes

Primary Outcomes

The occurrence of SUDEP or near-SUDEP

Baseline, clinical characteristics and EEG markers of SUDEP patients were collected.

Time frame: 2022.04.01-2024.04.01

Data from ClinicalTrials.gov

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