Effects of Collagen Peptide Supplementation on Muscle and Tendon Damage and Function

KU Leuven22 enrolled

Overview

The aim of the study is to investigate the acute and short-term effects of collagen peptides (Collagen Peptan) on muscle and connective tissue during an eccentric overload training period. Currently, all studies investigating the effects of post-exercise collagen supplementation did this in the absence of whey proteins, which are part of the standard recommendations for post-exercise recovery. The investigators will therefore investigate whether the combined intake of whey proteins and collagen peptides ensures a better recovery of exercise performance and whether it can prevent or reduce symptoms of muscle and tendon overload during a three-week eccentric overload training period (n = 22).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Exercise Healthy Male Subjects

Interventions

Eligibility

Sex: MALEMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Sports participation, including general fitness training, between 2 and 5 hours max per week * Body mass index between 18.5 and 25 Exclusion Criteria: * Any kind of injury/pathology that is a contra-indication to perform high-intensity exercise - Intake of any medication or nutritional supplement that could impact muscle protein synthesis and/or exercise performance during the period of the study * Intake of any whey protein, casein of branched-chain amino acid (BCAA) supplements from 1 month prior to the start of the study * Blood donation within 3 months prior to the start of the study * Smoking * Current participation in another research trial * Any other argument to believe that the subject is unlikely to successfully complete the full study

Outcomes

Primary Outcomes

Change in countermovement jump performance

Change in jump height when performing a countermovement jump, measured via a force platform

Time frame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)

Change in maximal isometric knee-extension force of the right leg

Change in maximal isometric knee-extension force (angle = 45°) of the right leg

Time frame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)

Change in anteroposterior thickness of the right patellar tendon

Time frame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)

Change in neovascularization of the right patellar tendon

Neovascularization of the right patellar tendon scored with the Modified Ohberg Score (range 0 - 4; the higher the score, the higher the degree of neovascularization).

Time frame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)

Secondary Outcomes

Change in pain perception at the muscular level (VAS scale)

Change in pain perception at the muscular level of the right leg, measured via the Visual Analogue Scale (range 0 - 10; the higher the score, the higher the pain level)

Time frame: Training 1 (day 1 of training intervention) - Training 2 (day 3 of training intervention) - Training 8 (day 9 of training intervention) - Training 17 (day 19 of training intervention) - Posttest (day 22 of training intervention)

Change in pain perception of the patellar tendon of the right leg (VISA-P)

Change in pain perception of the patellar tendon of the right leg, measured via the VISA-P questionnaire (range: 0 - 100; the lower the score, the higher the symptoms of patellar tendon overload)

Time frame: Pretest - Training 1 (day 1 of training intervention) - Training 17 (day 21 of training intervention) - Posttest (day 22 of training intervention)

Change in the blood concentration of creatine kinase

Change in blood concentration of creatine kinase (marker of muscle damage)

Time frame: Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)

Change in the blood concentration of Interleukin 6 (IL-6)

Change in blood concentration of Interleukin 6 (IL-6; marker of inflammation)

Time frame: Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)

Change in the blood concentration of N-terminal propeptide of type I procollagen (P1NP)

Change in blood concentration of N-terminal propeptide of type I procollagen (P1NP; marker of collagen synthesis)

Time frame: Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)

Effects of Collagen Peptide Supplementation on Muscle and Tendon Damage and Function

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes