This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.
To examine the brain's structure and specific language function and interactive relationships, investigators will implement repetitive or rapid TMS protocols in an active (or sham)-controlled, within-subject, randomized studies. Aims will evaluate the effects of short-term changes on each of the semantic or phonological language process of interest in isolation and changes in the interaction between language sub-processes and their interaction with other cognitive domains that directly or indirectly affect language functions. The brain targets for TMS application will be informed by existing evidence on (correlational but not causal) associations between language regions and specific language processes from numerous prior neuroimaging (e.g., functional magnetic resonance imaging or fMRI) and neuropsychological studies. Healthy individuals and/or stroke survivors with aphasia will be recruited to address these aims.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
135
Deymed DuoMag XT-100 rTMS
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
RECRUITINGReaction time on language task performance
Improvement on language task performance as measured by decrease in reaction time.
Time frame: Language tasks administered immediately before and/or after TMS administration (same day).
Accuracy on language task performance
Improvement on language task performance as measured by increase in accuracy.
Time frame: Language tasks administered immediately before and/or after TMS administration (same day).
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