This study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from EEG-fMRI data.
A group of patients with ischemic stroke and age/gender matched healthy controls would be enrolled in this study. Their features of neural activities based on EEG-fMRI fusion scan would be extracted to investigate the mechanisms of motor recovery after stroke. Particularly, the correlations of their features of neural networks or local activities to their motor function (defined as their Fugl-Meyer scores) at enrollment and their recovery time courses consisted of Fugl-Meyer scores in follow-up time points. Data of T1 structural, DSI fiber image and pure EEG (without MRI) would also be collected along with EEG-fMRI fusion data.
Study Type
OBSERVATIONAL
Enrollment
147
MRI imaging was performed using a 3 Tesla Siemens Prisma system with a 64-channel head/neck coil (Siemens Medical Systems, Erlangen, Germany). The MRI protocols included as follows: (i) Magnetization-Prepared 2 Rapid Acquisition Gradient Echoes: TR/TE/ TI1/TI2 = 5000/2.98/700/2500 ms, voxel size = 1.0 × 1.0 × 1.0 mm3, FOV = 256 × 240 × 176 mm3; (ii)Gradient-echo EPI: TR 720 ms, TE 33.1 ms, flip angle 52 deg, FOV 208x180 mm, Matrix 104x90, Slice thickness 2.0 mm; 72 slices; 2.0 mm isotropic voxels, Multiband factor 8, Echo spacing 0.58 ms, BW 2290 Hz/Px; (iii) DSI : TR/TE = 3300/73 ms, FOV = 220 × 220 × 60 mm3, voxel size = 2 × 2 × 2 mm3, 128 diffusion direction, b-max = 3000 sec/mm2, AT = 7:22 min); (iv) T2-weighted fluid-attenuated inversion recovery: TR/TE = 9000/84 ms, FOV = 270 × 320 × 22 mm2, voxel size = 0.72 × 0.72 × 6.6 mm3.
EEG was performed using a BrainAmp MR 32 amplifier (BrainProducts GmbH, München, Germany). The EEG protocols included as follows: (i) EEG-fMRI fusion: Sampling rate: 5000 Hz, low cut off-high cut off: DC-1000Hz;(2) EEG-fMRI fusion: Sampling rate: 1000 Hz, low cut off-high cut off: DC-1000Hz. In (i) an ECG channel would be used to collect artifact of pulse and not used in (ii).
Xi'an Daxing Hospital
Xi’an, Shanxi, China
Fugl-Meyer scores (T0)
a scale widely used to evaluate one's motor impairment
Time frame: 7-14 days since stroke
Fugl-Meyer scores (T1)
a scale widely used to evaluate one's motor impairment
Time frame: 6 weeks since stroke
Fugl-Meyer scores (T2)
a scale widely used to evaluate one's motor impairment
Time frame: 12 weeks since stroke
Fugl-Meyer scores (T3)
a scale widely used to evaluate one's motor impairment
Time frame: 72 weeks since stroke
Neuroimage features based on EEG-fMRI (T0)
Neuroimage features extracted from EEG-fMRI data
Time frame: 7-14 days since stroke
Neuroimage features based on EEG-fMRI (T1)
Neuroimage features extracted from EEG-fMRI data
Time frame: 6 weeks since stroke
Neuroimage features based on EEG-fMRI (T2)
Neuroimage features extracted from EEG-fMRI data
Time frame: 12 weeks since stroke
Neuroimage features based on EEG-fMRI (T3)
Neuroimage features extracted from EEG-fMRI data
Time frame: 72 weeks since stroke
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