investigator will see the efficacy of tranexamic acid in limb salvage surgery patients which will prevent blood loss and help in conservation of blood products.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
42
will inject tranexamic acid in limb salvage surgery of sarcoma patient to check its efficacy in preventing blood loss
normal saline will be injected to ensure placebo
Shaukat Khanum Memorial Cancer Hospital & Research Center
Lahore, Punjab Province, Pakistan
RECRUITINGblood loss
measure by hemoglobin direct method
Time frame: 72 hour post operatively
no of blood transfused
measured by number of transfusion
Time frame: 72 hour
duration of hospital stay
Total days of hospital admission 2 months after surgery
Time frame: total hospital stay post operatively for 02 month
volume of drain out put
to measure blood collected in drain bottle
Time frame: measure till drain out in 72 hour
thromboembolic events
look for limb swelling for deep vein thrombosis and chest symptoms for any embolic event confirmed by CT chest
Time frame: observed for 6 week determine on out patient visits
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