Intermittent theta-burst stimulation (iTBS) is a promising treatment for major depressive disorder. However, fewer than 50% of patients show sufficient response. Therefore, the optimal treatment protocol is worth investigating. Recent studies show that the relationship between stimulation intensity and prefrontal hemodynamic response is not linear but in an inverse U-shape by exploring the hemodynamic changes before and after iTBS. Concurrent transcranial magnetic stimulation (TMS)/functional near-infrared spectroscopy (fNIRS) setup allows the investigators to observe the prefrontal hemodynamic response during stimulation. The aim of this study is to investigate the effects of different intensities on brain activity during and after the stimulation using fNIRS.
Please refer to the full proposal
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
24
The iTBS will be applied over lDLPFC with three different intensities. The investigators put the NIRS probe under the TMS coil to detect the hemodynamic signal simultaneously, and the applied rMT was adjusted based on Stokes et al., 2007. The equation is AdjMT% = MT + 2.8 \* (Dsitex - Dm1), and the thickness of the probe is 6mm, therefore, 2.8\*6=16.8(%) were added to the normal intensity.
The Hong Kong Polytechnic University
Hong Kong, Hong Kong
Oxygenated hemoglobin (HbO) change compared to baseline
iTBS-induced HbO change in the DLPFC before, during and after stimulation
Time frame: During and post TBS-fNIRS measurement, up to 3 months
Deoxygenated hemoglobin (HbR) Change compared to baseline
iTBS-induced HbR change in the DLPFC before, during and after stimulation
Time frame: During and post TBS-fNIRS measurement, up to 3 months
Oxygen saturation change compared to baseline
iTBS-induced oxygen saturation change in the DLPFC before, during and after stimulation
Time frame: During and post TBS-fNIRS measurement, up to 3 months
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