This study will investigate the effect of caffeine and time of day on brain excitability using excitatory brain stimulation. The investigators will recruit a healthy participant and conduct a concurrent iTBS/fNIRS protocol for 20 consecutive sessions over four weeks with or without caffeine consumption before the stimulation. Moreover, the experiment will be conducted at different times of the day (morning or afternoon)
One healthy participant will be recruited for this study. The participants will be subjected to concurrent TBS/fNIRS, to which the iTBS will be applied on the left DLPFC and the NIRS will measure the prefrontal hemodynamic response simultaneously.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
1
The investigators will ask participant to only intake 200 mg of caffeine one hour before the experiment (no other caffeine intake since the wake-up) or avoid caffeine intake at all before the experiment
The investigators will ask participant to attend the experiment in the morning or afternoon
The Hong Kong Polytechnic University
Hong Kong, Hong Kong
Oxygenated hemoglobin (HbO) change compared to baseline
iTBS-induced HbO change in the DLPFC before, during and after stimulation
Time frame: During and post TBS-fNIRS measurement, up to 1 month
Deoxygenated hemoglobin (HbR) change compared to baseline
iTBS-induced HbO change in the DLPFC before, during and after stimulation
Time frame: During and post TBS-fNIRS measurement, up to 1 month
Oxygen saturation change compared to baseline
iTBS-induced HbO change in the DLPFC before, during and after stimulation
Time frame: During and post TBS-fNIRS measurement, up to 1 month
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