A Study of RGLS8429 in Healthy Volunteers

Inclusion Criteria: 1. Male or female, 18 to 55 years of age 2. Body mass index (BMI) 18 to 35 kg/m2 3. Medically healthy, with no clinically significant medical history in the opinion of the Investigator 4. Estimated glomerular filtration rate (eGFR) ≥ 90 mL/min/1.73 m2 5. Must understand and consent to the study procedures explained in the informed consent form (ICF) and be willing and able to comply with the protocol Exclusion Criteria: 1. Subject is mentally incapacitated or has significant emotional problems 2. Any medical condition or social circumstance that, in the opinion of the Investigator, may make the subject unlikely to complete the study or comply with study procedures and requirements, or may pose a risk to the subject's safety 3. History or presence of alcoholism or drug abuse within the past 2 years prior to Screening 4. Participation in another clinical trial and/or exposure to any investigational drug or approved therapy for investigational use within 28 days or 5 half-lives of the investigational drug's dosing, whichever is longer, prior to dosing. The 28-day and 5-half-life windows will be calculated from the date of the last dosing in the previous study to Day 1 of the current study.