This study will provide us with clear information about the postoperative concentration of antibiotic reached in synovial fluid, thereby helping surgeons to determine if concentration could potentially prevent the growth and regrowth of common infecting microorganisms (based on their MIC and MBEC). There is a need to define the actual benefit of antibiotic-loaded bone cement, because the addition of antibiotic can reduce its mechanical strength. Moreover, if sub-therapeutic antibiotic levels are achieved, this could facilitate the emergence of resistant bacterial strains. Amidst the transition towards value-based care, our research will enable surgeons to decide whether antibiotic-loaded cement is truly cost-effective in the prevention of PJI.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
50
Participants will have total knee arthroplasty
Total knee arthroplasty using Stryker Surgical Simplex P with tobramycin
Total knee arthroplasty using Huraeus Palacos R+G cement containing gentamicin
participants getting an antibiotic-loaded cement spacer during surgery comprised of vancomycin and tobramycin.
Rothman Orthopaedic Institute
Philadelphia, Pennsylvania, United States
Antibiotic concentration
To determine antibiotic levels, synovial fluid (joint fluid) would be taken after surgery to measure the concentration of antibiotic in the joint fluid
Time frame: 24 hours
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