Bispectral Index and Patient State Index During General Anesthesia With Remimazolam

N/AUnknownNCT05432050

Seoul National University Hospital40 enrolled

Overview

The aim of this study is to compare the bispectral index (BIS) and patient state index (PSI) during general anesthesia using remimazolam. The infusion rate of remimazolam is 6-12mg/kg/h during induction of anesthesia and 1-2mg/kg/h during maintenance of anesthesia. To calculate the fraction, the sum of times when BIS\<60 and PSI \<50 will be divided by the time from the loss of consciousness during induction of anesthesia to fully awake during emergence. We will compare the fraction of BIS \<60 and the fraction of PSI \<50 to find if there is some difference between the two depth of anesthesia monitoring devices during remimazolam anesthesia.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Remimazolam Anesthesia, General Hypnotics and Sedatives Thyroid Disease Breast Diseases Parathyroid Diseases

Interventions

Bispectral index and Patient state index monitoringDEVICE

The depth of anesthesia will be monitored with both the bispectral index and patient state index at the same time.

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients ≥ 19 years need general anesthesia * American Society of Anesthesiologists (ASA) Classification I, II * Written informed consent Exclusion Criteria: * American Society of Anesthesiologists (ASA) Classification III, IV, V * BMI \> 40kg/m\^2 * Past medical history of anaphylactic reaction to remimazolam, remifentanil, or other benzodiazepines. * Administration of anxiolytics, antipsychotics, rifampicin, succinylcholine, neostigmine, flumazenil, and cyclosporin within the past 24 hours * Benzodiazepine user (e.g. for seizure control) * Transfer to intensive care unit after surgery

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

The percentage of time when bispectral index (BIS) was < 60

The percentage of time when BIS was \< 60 (divided by the time between the loss of consciousness during induction of anesthesia and the full awakening during emergence from anesthesia.)