The purpose of this study is to explore the inflammatory biomarkers for the diagnosis of obstetric posterior reversible encephalopathy syndrome.
The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES to explore the inflammatory biomarkers for the diagnosis of oPRES during 2012 to 2021.Then, the investigators grouped all the patients into PRES group (PE or E with PRES) and NOT-PRES group (PE or E without PRES) according to the diagnostic criteria of PRES. Then, the investigators analysed the inflammatory biomarkers, such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), and so on of two groups, and compared the difference of tow groups.
Study Type
OBSERVATIONAL
Enrollment
621
According to the Diagnostic criteria of PRES, all the patients grouped into two groups.
Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
inflammatory biomarkers
The values of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and monocyte-lymphocyte ratio will be measured.
Time frame: Inflammatory biomarkers were collected within 1 day after the onset of symptoms.
cranial Imaging
According to the cranial Imaging, PE or E patients were grouped into PRES group (typical features presence of vasogenic edema in the white matter of the portions of both cerebral hemispheres) and NOT-PRES group (imaging findings were normal).
Time frame: Cranial Imaging was examined within 3 days after the onset of symptoms, such as s headaches, visual changes, seizures, consciousness impairment.
other biochemical parameters
The levels of C-Reactive protein (CRP) will be measured,and CRP﹥8000μg/L means a worse outcome.
Time frame: biochemical parameters were collected within 1 week of the hospital stay.
Blood Pressure(BP)
blood pressure including systolic blood pressure (SBP), and diastolic blood pressure (DBP).
Time frame: The BP of patients was obtained within 1hour after the onset of symptoms.
pregnancy outcomes
The rates of stillbirth and premature birth (gestation less than 37 weeks) in PRES patients.
Time frame: The pregnancy outcomes will record immediately when the patients deliver.
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