Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Hepatorenal Syndrome-Acute Kidney Injury

Cardiac output measurement by echocardiography

Echocardiographic assessment of cardiac output in L/min will be recorded at least 3 time points, day 0 and 48 hours after enrollment. The cardiac output at 7 days after enrollment will also be documented. he Doppler velocity time integral (VTI) method in estimating stroke volume and cardiac output correlates well with results of concurrent thermodilution cardiac output determinations in patients without significant left-sided valvular regurgitation. Cardiac output(CO), Stroke volume (SV), Heart rate (HR) CO = \[SV \* HR\]/ 1000

Time frame: Day 0, Day 2, Day 7.

IVC size and collapsibility changes

IVC maximum and Minimum diameter and collapsibility index determined by percentage change in IVC diameter will be recorded.

Time frame: Day 0.

IVC size and collapsibility changes

IVC maximum and Minimum diameter and collapsibility index determined by percentage change in IVC diameter will be recorded.

Time frame: Day 2

IVC size and collapsibility changes

IVC maximum and Minimum diameter and collapsibility index determined by percentage change in IVC diameter will be recorded.

Time frame: Day 7.

Number of patients with Complete Response in HRS-AKI

Complete response is defined as a reversal in AKI with a final serum Creatinine (sCr) value of ≤ 0.3 mg/dL of the baseline.

Time frame: Day 7

Number of patients with Partial Response in HRS-AKI

Partial response is defined as regression in the stage of AKI with a final sCr \> 0.3 mg/dL above the baseline.

Time frame: Day 7

Number of patients with Non-Response in HRS-AKI

Non-responder is defined if the sCr did not decrease or increased from the baseline.

Time frame: Day 7